Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-720 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HDAC1Antibody |
| AlternateNames |
|
| BackgroundInformation | MammalianHADC1(alsodesignatedHD1),HDAC2(alsodesignatedmammalianRPD3)andHDAC3,allarerelatedtotheyeasttranscriptionalregulatorRpd3p,areidentifiedashistonedeacetylases.Thedeacetylationofhistonesisassociatedwithtranscriptionalsilencing. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,containing0.05%sodiumazide.Frozenat-20ºC. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations: Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | UseAnti-HDAC1Antibody(RabbitPolyclonalAntibody)validatedinEA,ICC,IP,WBtodetectHDAC1alsoknownashistonedeacetylase1. |
| KeyApplications |
|
| ApplicationNotes | Immunoprecipitation: 5μgofapreviouslotimmunoprecipitatedHDAC1from500μgof3T3/A31RIPAlysate. Immunocytochemistry: ThisantibodyhasbeenreportedtoimmunostainHDAC1in1%paraformaldehydefixed,0.1%TritonX-100permeABIlized3T3cells. HDACActivity: ThisantibodyhasbeenreportedtoimmunoprecipitateactiveHDAC. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | 6X-His-taggedfragmentrepresentingaminoacids53-482ofmousehistonedeacetylase1(HDAC1). |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesandisspecificforHDAC1,Mr65kDa.Maydetectsanon-specificproteinat~35kDa. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Mouse,ratandhuman.Otherspeciescross-reactivitynottested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histoneacetylationanddeacetylation,catalyzedbymultisubunitcomplexes,playakeyroleintheregulationofeukaryoticgeneexpression.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamilyandisacomponentofthehistonedeacetylasecomplex.Italsointeractswithretinoblastomatumor-suppressorproteinandthiscomplexisakeyelementinthecontrolofcellproliferationanddifferentiation.Togetherwithmetastasis-associatedprotein-2,itdeacetylatesp53andmodulatesitseffectoncellgrowthandapoptosis.[providedbyRefSeq] |
| GeneSymbol |
|
| PurificationMethod | ProteinAchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q13547#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes. SIZE:482aminoacids;55103Da SUBUNIT:Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.Associateswiththe9-1-1complex;interactswithHUS1.FoundinacomplexwithDNMT3AandHDAC7.InteractswithBCOR,BRMS1L,DAXX,DNMT1,EP300,HCFC1,PCAF,PHB2,MIER1,JMJD2A/JHDM3A,MINT,NRIP1,RERE,SETDB1,SUV39H1,TGIF,TGIF2,UHRF1andUHRF2.Interactswiththenon-histoneregionofH2AFY.InteractswithHDAC9.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithBANP,CBFA2T3andJARID1B.InteractswithSAP30L. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Ubiquitous,withhigherlevelsinheart,pancreasandtestis,andlowerlevelsinkidneyandbrain. PTM:SumoylatedonLys-444andLys-476;whichpromotesenzymaticactivity.DesumoylatedbySENP1.&PhosphorylationonSer-421andSer-423promotesenzymaticactivityandinteractionswithNuRDandSIN3complexes. SIMILARITY:SwissProt:Q13547##Belongstothehistonedeacetylasefamily.Type1subfamily. |
| MolecularWeight | 65kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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