Millipore/05-897 |抗HDAC9抗体，克隆LH/JC2/05-897/100µ；L
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-897 |
| Replaces | MABE562 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HDAC9Antibody,cloneLH/JC2 |
| ProductInformation | |
|---|---|
| Format | Purified |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°Cfromdateofshipment |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | syntheticpeptidecorrespondingtoaminoacids1046-1060ofhumanHDAC9isoform5 |
| Clone | cloneLH/JC2 |
| Host | Rat |
| Specificity | HDAC9 |
| Isotype | IgM |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenehassequencehomologytomembersofthehistonedeacetylasefamily.ThisgeneisorthologoustotheXenopusandmouseMITRgenes.TheMITRproteinlacksthehistonedeacetylasecatalyticdomain.ItrepressesMEF2activitythroughrecruitmentofmulticomponentcorepressorcomplexesthatincludeCtBPandHDACs.Thisencodedproteinmayplayaroleinhematopoiesis.Multiplealternativelysplicedtranscriptshavebeendescribedforthisgenebutthefull-lengthnatureofsomeofthemhasnotbeendetermined. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9UKV0#Isoform3,calledMITR/HDRP,lacksactivesiteresiduesandthereforeiscatalyticallyinactive.RepressesMEF2-dependenttranscriptionbyrecruitingHDAC1and/orHDAC3.Seemstoinhibitskeletalmyogenesisandtobeinvolvedinheartdevelopment.Protectsneuronsfromapoptosis,bothbyinhibitingc-JunphosphorylationbyMAPK10andbyrepressingc-JuntranscriptionviaHDAC1recruitmenttoc-Junpromoter. SIZE:1011aminoacids;111297Da SUBUNIT:Homodimer.InteractswithCTBP1.Thephosphorylatedforminteractswith14-3-3(Bysimilarity).InteractswithHDAC1andHDAC3,andprobablywithHDAC4andHDAC5.InteractswithMEF2,MAPK10,ETV6,NCOR1andBCL6. SUBCELLULARLOCATION:Nucleus(Bysimilarity). TISSUESPECIFICITY:Broadlyexpressed,withhighestlevelsinbrain,heart,muscleandtestis.Isoform3ispresentinhumanbladdercarcinomacells(atproteinlevel). PTM:PhosphorylatedonSer-220andSer-450;whichpromotes14-3-3-binding,impairsinteractionwithMEF2,andantagonizesantimyogenicactivity.PhosphorylatedonSer-240;whichimpairsnuclearaccumulation(Bysimilarity).Isoform7isphosphorylatedonTyr-1010.&Sumoylated. DISEASE:SwissProt:Q9UKV0#AchromosomalaberrationinvolvingHDAC9isfoundinafamilywithPetersanomaly[MIM:604229].Translocationt(1;7)(q41;p21)withTGFB2resultinginlackofHDAC9protein.Petersanomalyconsistsofacentralcornealleukoma,absenceoftheposteriorcornealstromaandDescemetmembrane,andavariabledegreeofirisandlenticularattachmentstothecentralaspectoftheposteriorcornea. SIMILARITY:SwissProt:Q9UKV0##Belongstothehistonedeacetylasefamily.Type2subfamily. |
| MolecularWeight | 160kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
