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Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg
Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-814 |
| Replaces | 04-229 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HDAC2Antibody,clone3F3 |
| AlternateNames |
|
| BackgroundInformation | Histonedeacetylase2(HDAC2),ortranscriptionalregulatorhomologRPD3L1,ishighlyhomologoustotheyeasttranscriptionfactorRPD3(reducedpotassiumdependency3)gene.Asinyeast,humanHDA2islikelytobeinvolvedinregulatingchromatinstructureduringtranscription.IthasbeenimplicatedtoassociatewithYY1,amammalianzinc-fingertranscriptionfactor,whichnegativelyregulatestranscriptionbytetheringRPD3toDNAasacofactor.Thisprocessishighlyconservedfromyeasttohuman. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgGinbuffercontaining70%storagebuffer(0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide)and30%glycerol.Storeat-20°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptide(CEKTDTKGTKSEQLSNP)correspondingtoaminoacids473-488ofhumanHDAC2(Accession#NP_001518)containingaN-terminalcysteine |
| Clone | 3F3 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesHDAC2,MW~60kDa. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,mouse,bovineandhamster.Predictedtocross-reactwithratbasedonsequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneproductbelongstothehistonedeacetylasefamily.HistonedeacetylasesactviatheformationoflargemultiproteincomplexesandareresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalregionofthecorehistones(H2A,H2B,H3andH4).Thisproteinalsoformstranscriptionalrepressorcomplexesbyassociatingwithmanydifferentproteins,includingYY1,amammalianzinc-fingertranscriptionfactor.Thusitplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q92769#FormstranscriptionalrepressorcomplexesbyassociatingwithMAD,SIN3,YY1andN-COR.InteractsinthelateS-phaseofDNA-replicationwithDNMT1intheothertranscriptionalrepressorcomplexcomposedofDNMT1,DMAP1,PCNA,CAF1. SIZE:488aminoacids;55364Da SUBUNIT:Interactswiththenon-histoneregionofH2AFY(Bysimilarity).Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.PartofacomplexcontainingthecorehistonesH2A,H2B,H3andH4,DEKandunphosphorylatedDAXX.PartofacomplexcontainingATRandCHD4.FormsaheterologouscomplexatleastwithYY1.InteractswithATR,DNMT1,MINT,HDAC7,HDAC10,HCFC1,NRIP1,MJD2A/JHDM3A,SAP30,SETDB1andSUV39H1.Interactswiththenon-histoneregionofH2AFY.InteractswithPELP1.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithCBFA2T3.InteractswithSAP30L. SUBCELLULARLOCATION:Nucleus.TISSUESPECIFICITY:Widelyexpressed;lowerlevelsinbrainandlung. SIMILARITY:SwissProt:Q92769##Belongstothehistonedeacetylasefamily.Type1subfamily. |
| MolecularWeight | ~60kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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