当前位置：
首页
>
产品中心 >
Functional_antibody >
Millipore/05-813 | Anti-HDAC3 Antibody, clone 3G6/05-813/200 µg
Millipore/05-813 | Anti-HDAC3 Antibody, clone 3G6/05-813/200 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-813 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HDAC3Antibody,clone3G6 |
| BackgroundInformation | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.HDAC3belongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.HDAC3isregardedasapotentialtumorsuppressorgene. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30%. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | peptide(NEFYDGDHDNDKESDVEI)correspondingtoaminoacids411-428ofhumanHDAC3 |
| Clone | clone3G6 |
| Host | Mouse |
| Specificity | HDAC3 |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Predictedtocross-reactwithratandchickenbasedonsequencehomology |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.Thisgeneisregardedasapotentialtumorsuppressorgene. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:O15379#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.Probablyparticipatesintheregulationoftranscriptionthroughitsbindingtothezinc-fingertranscriptionfactorYY1;increasesYY1repressionactivity.RequiredtorepresstranscriptionofthePOU1F1transcriptionfactor. SIZE:428aminoacids;48848Da SUBUNIT:InteractswithHDAC7andHDAC9.FormsaheterologouscomplexatleastwithYY1.InteractswithDAXX,HDAC10andDACH1.FoundinacomplexwithNCOR1andNCOR2.ComponentoftheN-Correpressorcomplex,atleastcomposedofNCOR1,NCOR2,HDAC3,TBL1X,TBL1R,CORO2AandGPS2.InteractswithBCOR,MJD2A/JHDM3A,NRIP1andSRY.InteractswithBTBD14B.InteractswithGLIS2(Bysimilarity).InteractswithCBFA2T3. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Widelyexpressed. PTM:Sumoylatedinvitro. SIMILARITY:SwissProt:O15379##Belongstothehistonedeacetylasefamily.Type1subfamily. |
| MolecularWeight | 49-53kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
