Millipore/04-230 |抗HDAC3抗体，克隆Y415，兔单克隆/04-230/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-230 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-HDAC3Antibody,cloneY415,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.HistoneDeacetylase3(HDAC3)belongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.HDAC3isregardedasapotentialtumorsuppressorgenethatalsoplayscriticalrolesinSphaseprogressionandDNAdamagecontrol. |
| ProductInformation | |
|---|---|
| Format | CultureSupernatant |
| Control |
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| Presentation | UnpurifiedrabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLHconjugatedtoasyntheticpeptidefromtheC-terminalregionofhumanHistoneDeacetylase3. |
| Epitope | C-terminus |
| Clone | Y415 |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesHistoneDeacetylase3attheC-terminus. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithhuman,mouseandratHDAC3. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents. Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.Thisgeneisregardedasapotentialtumorsuppressorgene.[providedbyRefSeq]. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.Probablyparticipatesintheregulationoftranscriptionthroughitsbindingtothezinc-fingertranscriptionfactorYY1;increasesYY1repressionactivity.RequiredtorepresstranscriptionofthePOU1F1transcriptionfactor. CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone. SUBUNIT:InteractswithHDAC7andHDAC9.FormsaheterologouscomplexatleastwithYY1.InteractswithDAXX,HDAC10andDACH1.FoundinacomplexwithNCOR1andNCOR2.ComponentoftheN-Correpressorcomplex,atleastcomposedofNCOR1,NCOR2,HDAC3,TBL1X,TBL1R,CORO2AandGPS2.InteractswithBCOR,MJD2A/JHDM3A,NRIP1andSRY.InteractswithBTBD14B.InteractswithGLIS2Bysimilarity.InteractswithCBFA2T3. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Widelyexpressed. PTM:Sumoylatedinvitro.Ref.14 SIMILARITY:Belongstothehistonedeacetylasefamily.Type1subfamily. |
| MolecularWeight | 49kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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