Millipore/MAB5224 |抗Internexinα抗体，CT，克隆2E3/MAB5224/300µ；L
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5224 |
| Replaces | 04-1032 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-InternexinαAntibody,CT,clone2E3 |
| BackgroundInformation | Theproteinalpha-internexinisa~66kDaClassIVintermediatefilamentoriginallydiscoveredasitcopurifieswithotherneurofilamentsubunits{PachterJetalJ.CellBiol101:1316-22(1985).Itisrelatedtobutdistinctfromthebetterknownneurofilamenttripletproteins,NF-L,NF-MandNF-H,havingsimilarproteinsequencemotifsandasimilarintronorganization.Itisexpressedinlargeamountsearlyinneuronaldevelopment,butisdownregulatedinmanyneuronsasdevelopmentprocedes.Manyclassesofmatureneuronscontainalpha-internexininadditiontoNF-L,NF-ManBDNF-H.Insomematureneuronsalpha-internexinistheonlyneurofilamentsubunitexpressed.Antibodiestoa-internexinarethereforeuniqueprobestostudyandclassifyneuronaltypesandfollowtheirprocessesinsectionsandintissueculture.Inadditiontheveryearlydevelopmentalexpressionofalpha-internexinmeansitspresenceisanearlyandconvenientdiagnosticfeatureofneuronalProgenitorscellsandothercellcommittedtotheneuronallineage.Inadditionrecentstudiesshowamarkedup-regulationofa-internexinduringneuronalregeneration{McGrawetal2002}.Theuseofantibodiestothisproteininthestudyofbraintumorshasnotbeenexaminedtodate,butislikelytobeofinterest. |
| ProductInformation | |
|---|---|
| Format | CultureSupernatant |
| Presentation | MouseIgGinlowserum(1%),tissueculturesupernatantcontainingnopreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | ThisAnti-InternexinAntibody,α,C-terminus,clone2E3isvalidatedforuseinELISA,IP,WB,IH(P)forthedetectionofInternexin. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:antibodydetectsaproteinbandat55-66kDa,asexpectedforalphainternexin{Evans,etal,2001}. ImmunocytochemistryonPC12andNtera-2cells. Immunohistochemistryonformalinandmethanolfixedtissues.Worksonparaffinembeddedtissuesections. Immunoprecipitation ELISA Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Fulllengthrecombinantratalphainternexin. |
| Epitope | C-terminus |
| Clone | 2E3 |
| Host | Mouse |
| Specificity | Alphainternexin.LocalizedtotheC-terminal164aminoacidsofratalphainternexin. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q16352#Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. SIZE:499aminoacids;55391Da TISSUESPECIFICITY:FoundpredominantlyinadultCNS. DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation. PTM:O-glycosylated(Bysimilarity).&PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:Q16352##Belongstotheintermediatefilamentfamily. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
