4000-520-616
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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/05-848 | Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3/05-848/200 µL
商品详细Millipore/05-848 | Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3/05-848/200 µL
Millipore/05-848 | Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3/05-848/200 µL
Millipore/05-848 | Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3/05-848/200 µL
商品编号: 05-848
品牌: 密理博
市场价: ¥7800.00
美元价: 4680.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber05-848
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionAnti-NeurofilamentAntibody,heavychain,KEPsegment,clone3G3
ProductInformation
FormatAscites
PresentationAscitesin0.05%sodiumazideand30%glycerol
StorageandShippingInformation
StorageConditions2yearsat-20°C
Applications
ApplicationThisAnti-NeurofilamentAntibody,heavychain,KEPsegment,clone3G3isvalidatedforuseinWB,IC,IHforthedetectionofNeurofilament.
KeyApplications
  • WesternBlotting
  • Immunocytochemistry
  • Immunohistochemistry
BIOLOGicalInformation
ImmunogenTrp-Efusionproteincorrespondingtoresidues846-1072ofratneurofilamentheavychain.
Clone3G3
HostMouse
SpecificityNeurofilamentheavychain
IsotypeIgG
SpeciesReactivity
  • Mouse
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • NEFH
  • NF-H
  • KIAA0845
  • NFH
PurificationMethodAscites
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P12036#Neurofilamentsusuallycontainthreeintermediatefilamentproteins:L,M,andHwhichareinvolvedinthemaintenanceofneuronalcaliber.NF-HhasanimportantfunctioninmatureaxonsthatisnotsubservedbythetwosmallerNFproteins.
SIZE:1026aminoacids;112480Da
PTM:ThereareanumberofrepeatsofthetripeptideK-S-P,NFHisphosphorylatedonanumberoftheserinesinthismotif.ItisthoughtthatphosphorylationofNFHresultsintheformationofinterfilamentcrossbridgesthatareimportantinthemaintenanceofaxonalcaliber.&Phosphorylationseemstoplayamajorroleinthefunctioningofthelargerneurofilamentpolypeptides(NF-MandNF-H),thelevelsofphosphorylationbeingaltereddevelopmentallyandcoincidentwithachangeintheneurofilamentfunction.
DISEASE:SwissProt:P12036#DefectsinNEFHareacauseofsusceptibilitytoamyotrophiclateralsclerosis(ALS)[MIM:105400].ALSisaneurodegenerativedisorderaffectingupperandlowermotorneurons,andresultinginfatalparalysis.Sensoryabnormalitiesareabsent.Deathusuallyoccurswithin2to5years.Theetiologyislikelytobemultifactorial,involvingbothgeneticandenvironmentalfactors.
SIMILARITY:SwissProt:P12036##Belongstotheintermediatefilamentfamily.
MolecularWeight200kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。