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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/04-1032 | Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal/04-1032/100 µL
商品详细Millipore/04-1032 | Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal/04-1032/100 µL
Millipore/04-1032 | Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal/04-1032/100 µL
Millipore/04-1032 | Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal/04-1032/100 µL
商品编号: 04-1032
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber04-1032
DescriptionAnti-Neurofilament-66Antibody,cloneEP676Y,rabbitmonoclonal
AlternateNames
  • 66kDaneurofilamentprotein
  • internexinneuronalintermediatefilamentprotein
  • alpha
  • neurofilament5(66kD)
  • neurofilament-66
  • tax-bindingprotein
BackgroundInformationNeurofilament-66,alsoknownasα-internexin,isamemberoftheIFfamily.ItisfoundindevelopingneuroblastsandintheCNSofadults.Neurofilament-66isexpressedintheadultbrainatlowerlevelsthanotherneurofilamentproteins.
ProductInformation
FormatUnpurified
Control
  • SHSY5Ycelllysate
PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
StorageandShippingInformation
StorageConditionsStablefor1yearat-20ºCfromdateofreceipt.
HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
Applications
ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry(Paraffin)
  • Immunocytochemistry
  • Immunoprecipitation
  • FlowCytometry
ApplicationNotesImmunohistochemistryAnalysis:A1:250-500dilutionfromapreviouslotdetectedNeurofilament-66inhumanbraintissuebutnotinhumancolon,kidneyoruterus.
ImmunocytochemistryAnalysis:A1:250-500dilutionfromapreviouslotdetectedNeurofilament-66inPC12cells.
FlowCytometry:A1:25dilutionofapreviouslotwasusedinflowcytometry.
ImmunoprecipitationAnalysis:A1:50dilutionfromapreviouslotwasusedinIP.
BIOLOGicalInformation
ImmunogenSyntheticpeptidecorrespondingtoresiduesinthetaildomainofhumanNeurofilament-66.
EpitopeTailDomain
CloneEP676Y
HostRabbit
SpecificityThisantibodyrecognizesNeurofilament-66atandaroundthetaildomain.
IsotypeIgG
SpeciesReactivity
  • Human
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryNeurofilamentsaretypeIVintermediatefilamentheteropolymerscomposedoflight,medium,andheavychains.Neurofilamentscomprisetheaxoskeletonandtheyfunctionallymaintaintheneuronalcaliber.Theymayalsoplayaroleinintracellulartransporttoaxonsanddendrites.Thisgeneisamemberoftheintermediatefilamentfamilyandisinvolvedinthemorphogenesisofneurons.
GeneSymbol
  • Alpha-Inx
  • FLJ18662
  • FLJ57501
  • MGC12702
  • NEF5
  • NF-66
  • Neurofilament-66
  • OTTHUMP00000020403
  • TXBP-1
PurificationMethodUnpurified
UniProtNumber
UniProtSummaryFUNCTION:Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges.
TISSUESPECIFICITY:FoundpredominantlyinadultCNS.
DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation.
PTM:O-glycosylatedBysimilarity.
PhosphorylateduponDNAdamage,probablybyATMorATR.
SEQUENCESIMILARITIES:Belongstotheintermediatefilamentfamily.
MolecularWeight~66kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。