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Millipore/MAB3738 | Anti-PML Antibody, clone 36.1-104/MAB3738/100 µL
Millipore/MAB3738 | Anti-PML Antibody, clone 36.1-104/MAB3738/100 µL
市场价：
¥6360.00
美元价：
3816.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB3738 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-PMLAntibody,clone36.1-104 |
| AlternateNames |
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| BackgroundInformation | PMLproteinisatripartitemotif(TRIM)-containingnuclearproteinthatmayfunctionas,amongotherthings,atranscriptionfactor,acoactivatorofnuclearreceptors(Ruggerio,2000),aregulatorofapoptosis(Guo,2000),amediatorofinterferon-inducedantiviralresponse(RegandandChelbi-Aliz,2001),andasasuppressorofgrowthandoncogenictransformation(Mu,1997).PMLislocalizedtothenucleoplasmandindistinctsubnuclearstructuresreferredtoasPromyelocyticLeukemiaBodies(alsoknownasNuclearDomain10).LocalizationofPMLtoPromyelocyticLeukemiaBodiesrequiresmodificationofPMLproteinbytheSmallUbiquitinModifier(SUMO)andisrequiredforproperformationandintegrityofthesesubnuclearstructures.Atleast14splicevariantsofPMLranginginmolecularweightfrom48-97kDa(predicted)havebeendescribedintheliterature.Thefunctionalsignificanceofthevarioussplicevariantsisnotwellunderstood.InpatientswithAcutePromyelocyticLeukemia,thePMLgeneisinvolvedinatleasttwospecificchromosomaltranslocationsthatresultintheexpressionofchimericproteinswiththeRetinoicAcidReceptoralpha(RARalphaDNA-andHormone-bindingdomains;Pandolfi,2001).AllisoformsofPML,aswellasthePML-RARalphachimericproteinsexpressedinTypeAandTypeBAPLcontainanidenticalN-terminusbutvaryintheC-terminalportionoftheprotein(Jenson,2001). |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
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| Presentation | Ascitesfluidcontainingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | His-taggedPMLfusionproteincorrespondingtoaminoacids1-581ofmousePML. |
| Clone | 36.1-104 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesmousePML(PromyelocyticLeukemiaprotein).Onwesternblotsofproteinextractsfrommouseembryofibroblast(MEF1cells),MAB3738recognizesabandmigratingatapproximately106kDacorrespondingtoPML. |
| Isotype | IgG2b |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. |
| GeneSymbol |
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| Non-ReactiveSpecies |
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| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies. SIZE:882aminoacids;97517Da SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity). SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies. PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation. DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon. SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger. |
| MolecularWeight | 106kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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