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Millipore/05-718 | Anti-PML Antibody, clone 36.1-104/05-718/200 µg
Millipore/05-718 | Anti-PML Antibody, clone 36.1-104/05-718/200 µg
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-718 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-PMLAntibody,clone36.1-104 |
| BackgroundInformation | PromyelocticLeukemiaGeneproduct(PML)isanuclearproteinwithgrowth-suppressivepropertiesoriginallyidentifiedinthecontextofthePML-retinoicreceptoralpha(RARalpha)fusionproteinofacutepromyelocyticleukemia.PMLlocalizeswithindistinctnuclearstructures,callednuclearbodies,whicharedisruptedbytheexpressionofPML-RARalpha. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ProteinGPurifiedimmunoglobulinin0.1MTris-glycine,pH7.4,0.15MNaClwith0.05%sodiumazideasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | 6HisfusionproteincorrespondingtomousePML(promyelocyticleukemiaprotein) |
| Clone | 36.1-104 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesPML. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies. SIZE:882aminoacids;97517Da SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity). SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies. PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation. DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon. SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger. |
| MolecularWeight | 90-106kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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