密理博/AB3006 |抗CREB抗体/AB3006/100µ；L
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB3006 |
| Replaces | 04-218 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-CREBAntibody |
| AlternateNames |
|
| BackgroundInformation | CREBisabetaZIPtranscriptionfactorthatactivatestargetgenesthroughcAMPresponseelements.CREBisabletomediatesignalsfromnumerousphysiologicalstimuli,resultinginregulationofabroadarrayofcellularresponses.WhileCREBisexpressedinnumeroustissues,itplaysalargeregulatoryroleinthenervoussystem.CREBisbelievedtoplayakeyroleinpromotingneuronalsurvival,precursorproliferation,neuriteoutgrowthandneuronaldifferentiationincertainneuronalpopulations.Additionally,CREBsignalingisinvolvedinlearningandmemoryinseveralorganisms.CREBisabletoselectivelyactivatenumerousdownstreamgenesthroughinteractionswithdifferentdimerizationpartners.CREBisactivatedbyphosphorylationatSer133byvarioussignalingpathwaysincludingErk,Ca2+andstresssignaling.SomeofthekinasesinvolvedinphosphorylatingCREBatSer133arep90RSK,MSK,CaMKIVandMAPKAPK-2. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedimmunoglobulin.Liquid(sterilefiltered)in0.02MPotassiumPhosphatebuffercontaining0.15MSodiumChloride,pH7.2with0.01%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfrozenat-20°Cinundilutedaliquotsforuptosixmonths.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | UseAnti-CREBAntibody(RabbitPolyclonalAntibody)validatedinELISA,EMSA,IP,WBtodetectCREBalsoknownasCREB-1,cAMP-responseElement-bindingProtein-1. |
| KeyApplications |
|
| ApplicationNotes | Immunoblot Immunoprecipitation ELISA Supershiftassay:0.5-1.0μLperassay. Optimaldilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | CREB-1(p43)peptidecorrespondingtotheN-terminal(aa5-45)ofhumanproteinconjugatedtoKLH. |
| Host | Rabbit |
| Specificity | HumancyclicAMPresponsiveelementbindingprotein-1(CREB-1,p43).ByWesternblotitshowsamajorbandat46kDawhenassayedagainstalysateof1x106RajiBcells.Minorbandsat75kDaand43kDamaybenoted.PartialreactivitytoCREM-1protein.Mayreactnon-specificallywithotherproteins. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16220#ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE. SIZE:341aminoacids;36688Da SUBUNIT:BindsDNAasadimer.InteractsPPRC1andwithHTLV-1Tax-1. SUBCELLULARLOCATION:Nucleus. PTM:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircADIanrhythmgeneration.PhosphorylationofSer-133allowsCREBBPandEP300binding(Bysimilarity).PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P16220##BelongstothebZIPfamily.&Contains1bZIPdomain.&Contains1KID(kinase-inducIBLe)domain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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