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Millipore/05-667 | Anti-phospho-CREB (Ser133) Antibody, clone 10E9/05-667/100 µg
Millipore/05-667 | Anti-phospho-CREB (Ser133) Antibody, clone 10E9/05-667/100 µg
市场价：
¥8420.00
美元价：
5052.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-667 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-phospho-CREB(Ser133)Antibody,clone10E9 |
| AlternateNames |
|
| BackgroundInformation | CREBisabetaZIPtranscriptionfactorthatactivatestargetgenesthroughcAMPresponseelements.CREBisabletomediatesignalsfromnumerousphysiologicalstimuli,resultinginregulationofabroadarrayofcellularresponses.WhileCREBisexpressedinnumeroustissues,itplaysalargeregulatoryroleinthenervoussystem.CREBisbelievedtoplayakeyroleinpromotingneuronalsurvival,precursorproliferation,neuriteoutgrowthandneuronaldifferentiationincertainneuronalpopulations.Additionally,CREBsignalingisinvolvedinlearningandmemoryinseveralorganisms.CREBisabletoselectivelyactivatenumerousdownstreamgenesthroughinteractionswithdifferentdimerizationpartners.CREBisactivatedbyphosphorylationatSer133byvarioussignalingpathwaysincludingErk,Ca2+andstresssignaling.SomeofthekinasesinvolvedinphosphorylatingCREBatSer133arep90RSK,MSK,CaMKIVandMAPKAPK-2. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1κfromserum-freecellculturesupernatant,lyophilizedfrom1mLofPBS,0.09%sodiumazide,PEG,andsucrose.Lyophilized. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Lyophilized:Stablefor1yearat-20ºCfromdateofreceipt. Rehydrated:Stablefor3monthsat2-8ºC. Aliquotsolutiontostorefrozenandavoidrepeatedfreezethawcycles. |
| Applications | |
|---|---|
| Application | Anti-phospho-CREB(Ser133)Antibody,clone10E9isaMouseMonoclonalAntibodyfordetectionofphospho-CREB(Ser133)alsoknownasactivetranscriptionfactorCREB&hasbeenvalidatedinWB,ELISA. |
| KeyApplications |
|
| ApplicationNotes | ELISA:Recommendedat0.05μg/mLbyanindependentlaboratory. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptide(REILSRRP(pS)YR)correspondingtoaminoacids125-135ofhumanCREB.Theimmunizingsequenceisidenticalinhumanandmouse.Clone10E9. |
| Clone | clone10E9 |
| Host | Mouse |
| Specificity | RecognizesphosphorylatedCREBatMr46kDa.Mayalsorecognizep30andp38proteins,whichlikelycorrespondtophosphorylatedCREMandATF-1respectively,sincethetwoproteinssharesignificanthomologywiththephosphorylatedCREBimmunizingpeptide |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesatranscriptionfactorthatisamemberoftheleucinezipperfamilyofDNAbindingproteins.ThisproteinbindsasahomodimertothecAMP-responsiveelement,anoctamericpalindrome.Theproteinisphosphorylatedbyseveralproteinkinases,andinducestranscriptionofgenesinresponsetohormonalstimulationofthecAMPpathway.Alternatesplicingofthisgeneresultsintwotranscriptvariantsencodingdifferentisoforms. |
| GeneSymbol |
|
| Modifications |
|
| PurificationMethod | Thiophilicadsoptionandsizeexclusionchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16220#ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE. SIZE:341aminoacids;36688Da SUBUNIT:BindsDNAasadimer.InteractsPPRC1andwithHTLV-1Tax-1. SUBCELLULARLOCATION:Nucleus. PTM:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircADIanrhythmgeneration.PhosphorylationofSer-133allowsCREBBPandEP300binding(Bysimilarity).PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P16220##BelongstothebZIPfamily.&Contains1bZIPdomain.&Contains1KID(kinase-inducIBLe)domain. |
| MolecularWeight | 46kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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