微孔/ABS82 |抗VEGF抗体/ABS82/100µ；G
市场价：
¥5740.00
美元价：
3444.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABS82 |
| Replaces | 07-1376 |
| Description | Anti-VEGFAntibody |
| AlternateNames |
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| BackgroundInformation | VEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.VEGFinducesangiogenesisaswellaspermeabilizationofbloodvessels,andplaysacentralroleintheregulationofvasculogenesis.VEGFexpressioncorrelatestothedegreeoftumorvascularizationandwithincreasedmetastaticrisk.Additionally,VEGFinducesendothelialcellproliferation,promotescellmigration,andinhibitsapoptosis.Consequently,inhibitionofVEGFsignalingabrogatesthedevelopmentofawidevarietyoftumors. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BiologicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtohumanVEGFattheN-terminus. |
| Epitope | N-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesVEGFattheN-terminus. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithprimatebasedon100%sequencehomology. Otherhomologies:Bovine(85%sequencehomology).Rat(70%sequencehomology).Mouse(65%sequencehomology). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.[providedbyRefSeq]. |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145. SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity). SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing. |
| MolecularWeight | ~55kDaobserved.UniProtKB/Swiss-ProtP15692(VEGFA_HUMAN)entrydescribes13isoformsproducedbyalternativepromoterusage,alternativesplicingandalternativeinitiation:Isoform1at27.042kDa,Isoform2at25.173kDa,Isoform3at24.422kDa,Isoform4at22.314kDa,Isoform5at20.218kDa,Isoform6at20.064kDa,Isoform7at22.259kDa,Isoform8at17.219kDa,Isoform9at15.981kDa,Isoform10at40.738kDa,Isoform11at35.643kDa,Isoform12at43.597kDa,Isoform13at45.467kDa. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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