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Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg
Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-443 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-VEGFAntibody,cloneJH |
| AlternateNames |
|
| BackgroundInformation | TheFltgenefamilyofreceptortyrosinekinasesincludesFlt-1,KDR/Flk-1,Flt-3,andFlt-4.TheyencodereceptorsforVEGF,characterizedbysevenIg-loopswithintheirextracellulardomainandasplitkinasedomainwithinthecytoplasmicdomain.VEGFisanimportantangiogenicfactorofmanysolidtumorsandisalsoinvolvedinthedifferentiationofendothelialcells.Flt-1(Fms-liketyrosinekinase,VEGF-R1)isexpressedonendothelialcellsandonthecommonprecursorsofendothelialandhematopoieticstemcells.KDR(Flk-1,VEGF-R2)istheprincipalreceptorinvolvedinVEGFsignaling.KDRisexpressedonendothelialcellsandstimulatesangiogenesis,butisalsoexpressedonbonemarrowcells,andisthoughttoplayaroleindrivingtheproliferationofmostorallleukemiccells.Flt3isaclassIIIreceptortyrosinekinasethatiscloselyrelatedtoc-Kitandc-Fms.Itisexpressedinprimitivehematopoieticcellsanditsligandexertsproliferativeeffectsonthesecellsinco-operationwithothercytokines.Flt3isalsoexpressedtheplacenta,testis,spleen,thymus,bonemarrow,brainandincerebellarPurkinjecells.TheVEGFreceptorsstimulatetheRas-MAPkinasepathway,suggestingthatitsignalsasaconventionalreceptortyrosinekinase. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1kinbuffercontaining10mMPBS,pH7.4. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearatfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinanthumanVEGF121.CloneJH121 |
| Clone | cloneJH |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Recognizes34-54kDaisoformsofVascularEndothelialGrowthFactor/VascularPermeabilityFactor(VEGF/VPF). |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,rabbit,mouse,andrat.Otherspeciesnottested. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms. |
| GeneSymbol |
|
| PurificationMethod | ProteinGChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P15692#Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145. SIZE:232aminoacids;27042Da SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity). SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon. SIMILARITY:SwissProt:P15692##BelongstothePDGF/VEGFgrowthfactorfamily. |
| MolecularWeight | 34-54kDaisoforms |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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