4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:分子类,蛋白类,抗体类,生化类试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/05-1117 | Anti-VEGF Antibody, clone VG1/05-1117/100 µL
商品详细Millipore/05-1117 | Anti-VEGF Antibody, clone VG1/05-1117/100 µL
Millipore/05-1117 | Anti-VEGF Antibody, clone VG1/05-1117/100 µL
Millipore/05-1117 | Anti-VEGF Antibody, clone VG1/05-1117/100 µL
商品编号: 05-1117
品牌: 密理博
市场价: ¥5960.00
美元价: 3576.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber05-1117
ReplacesMAB3734
DescriptionAnti-VEGFAntibody,cloneVG1
AlternateNames
  • VascularpermeABIlityfactor
  • vascularendothelialgrowthfactor
  • vascularendothelialgrowthfactorA
  • vascularendothelialgrowthfactorisoformVEGF165
BackgroundInformationVEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.
ProductInformation
FormatAscites
Control
  • NIH/3T3celllysate
PresentationUnpurifiedmousemonoclonalIgG1κinascitesfluidcontainingnopreservatives.
StorageandShippingInformation
StorageConditionsStablefor12monthsat-20°Cfromdateofreceipt.
Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
Applications
ApplicationDetectVEGFusingthisAnti-VEGFAntibody,cloneVG1validatedforuseinWB.
KeyApplications
  • WesternBlotting
BiologicalInformation
ImmunogenRecombinanthumanVEGF189aaisoform
CloneVG1
HostMouse
SpecificityDetectsthe121,165,and189aminoacidisoformsofVEGF.
IsotypeIgG1κ
SpeciesReactivity
  • Human
  • Mouse
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneproductisamemberofthePDGF/VEGFgrowthfactorfamily.Itisamitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesis,endothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.Also,alternativetranslationinitiationfromnon-AUG(CUG)andAUGstartsitesinsometranscriptvariants,giverisetoadditionalisoforms.
GeneSymbol
  • MGC70609
  • VPF
  • VEGF-A
  • VEGF
  • MVCD1
PurificationMethodUnpurified
UniProtNumber
UniProtSummaryFUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.
SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity).
SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.
ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing.
MolecularWeightApprox.12-28kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。