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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/05-1116 |抗VEGF抗体,克隆CH-10/05-1116/100µ;G
商品详细Millipore/05-1116 |抗VEGF抗体,克隆CH-10/05-1116/100µ;G
Millipore/05-1116 |抗VEGF抗体,克隆CH-10/05-1116/100µ;G
Millipore/05-1116 |抗VEGF抗体,克隆CH-10/05-1116/100µ;G
商品编号: 05-1116
品牌: 密理博
市场价: ¥5960.00
美元价: 3576.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber05-1116
ReplacesMAB1665
DescriptionAnti-VEGFAntibody,cloneCH-10
AlternateNames
  • VascularpermeABIlityfactor
  • vascularendothelialgrowthfactor
  • vascularendothelialgrowthfactorA
  • vascularendothelialgrowthfactorisoformVEGF165
BackgroundInformationVEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.
ProductInformation
FormatAffinityPurified
Control
  • Jurkatcelllysate
PresentationLiquidin20mMsodiumphosphate,250mMNaCl,pH.7.6containing0.1%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationAnti-VEGFAntibody,cloneCH-10isanantibodyagainstVEGFforuseinWB.
KeyApplications
  • WesternBlotting
BiologicalInformation
ImmunogenRecombinantmouseVEGF.
CloneCH-10
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityThisantibodyrecognizeshumanandratVEGF,othervariantsnottested.
IsotypeIgG1
SpeciesReactivity
  • Human
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneproductisamemberofthePDGF/VEGFgrowthfactorfamily.Itisamitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesis,endothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.Also,alternativetranslationinitiationfromnon-AUG(CUG)andAUGstartsitesinsometranscriptvariants,giverisetoadditionalisoforms.
GeneSymbol
  • MGC70609
  • MVCD1
  • VEGF
  • VEGF-A
  • VPF
PurificationMethodAffinityPurfied
UniProtNumber
UniProtSummaryFUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.IsoformVEGF165BbindstoVEGFR2/Kdrbutdoesn"tactivatedownstreamsignalingpathways,doesn"tactivateangiogenesisandinhibitstumorgrowth.
SUBUNITSTRUCTURE:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGFBysimilarity.
SUBCELLULARLOCATION:Secreted.Note:VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.
TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon.
INDUCTION:Regulatedbygrowthfactors,cytokines,gonadotropins,nitricoxide,hypoxia,hypoglycemiaandoncogenicmutations.
SEQUENCESIMILARITIES:BelongstothePDGF/VEGFgrowthfactorfamily.
SEQUENCECAUTION:ThesequenceCAC19512.2differsfromthatshown.Reason:Erroneousgenemodelprediction.
MolecularWeight12/16/19kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。