密理博/MAB1387Z |抗CD11b抗体，克隆M1/70.15.1，无叠氮/MAB1387Z/100µ；G
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1387Z |
| Replaces | MAB88919 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-CD11bAntibody,cloneM1/70.15.1,azidefree |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedratimmunoglobulininPBScontainingnopreservatives |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | Anti-CD11bAntibody,cloneM1/70.15.1,azidefreeisanantibodyagainstCD11bforuseinFC,IF,IH&IP. |
| KeyApplications |
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| ApplicationsNotRecommended |
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| ApplicationNotes | FlowCytometry1:50-1:100 Immunohistologyonfreshfrozenoracetonefixedtissues. ImmunohistochemistryonparaffinembeddedtissuesfixedinPLP,methyl-carnoy,or2%PFA;trADItional10%formalinfixationisproblematic. Immunoprecipitation:usearabbitanti-ratcaptureantibodyratherthanproteinGorA. Functional/blockingofC3bibindingtoitsreceptor. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | TcellenrichedsplenocytesfromB10mice |
| Clone | M1/70.15.1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Specificity | RecognizesthemurinealphaMintegrinchain,whichexistsasaheterodimerwiththebeta2integrin(Springer,1979;Springer,1990).Theantibodystainspolymorphonuclearcells,monocytesandNKcells.Variableactivityisreportedwithtissuemacrophages.M1/70.15.1blocksiC3bbindingtoitsreceptor(Beller,1982). |
| Isotype | IgG2b |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodestheintegrinalphaMchain.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.ThisI-domaincontainingalphaintegrincombineswiththebeta2chain(ITGB2)toformaleukocyte-specificintegrinreferredtoasmacrophagereceptor1("Mac-1"),orinactivated-C3b(iC3b)receptor3("CR3").ThealphaMbeta2integrinisimportantintheadherenceofneutrophilsandmonocytestostimulatedendothelium,andalsointhephagocytosisofcomplementcoatedparticles.SomeintegrinalphaMproteinscontainaninsertedaminoacid(Q,betweenAApositions499and500)resultingfroma3bpshiftinaspliceacceptorthatinsertsthecodonCAG;receptorswithorwithouttheextraaminoacidarefunctionallyindistinguishable |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P11215#Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SIZE:1152aminoacids;127179Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes. DOMAIN:SwissProt:P11215TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage. SIMILARITY:Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats.&Contains1VWFAdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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