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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > Millipore/17-191 | MAP Kinase/Erk Assay Kit, non-radioactive/17-191/1 kit
商品详细Millipore/17-191 | MAP Kinase/Erk Assay Kit, non-radioactive/17-191/1 kit
Millipore/17-191 | MAP Kinase/Erk Assay Kit, non-radioactive/17-191/1 kit
Millipore/17-191 | MAP Kinase/Erk Assay Kit, non-radioactive/17-191/1 kit
商品编号: 17-191
品牌: 密理博
市场价: ¥10580.00
美元价: 6348.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber17-191
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionMAPKinase/ErkAssayKit,non-rADIoactive
ProductInformation
Components
  • AssayDilutionBufferI(ADBI)(Cat.#20-108)
  • MAPKinase/ErkSubstrateCocktailII(Cat.#20-166)
  • InhibitorCocktail(Cat.#20-116)
  • Magnesium/ATPCocktail(Cat.#20-113)
  • Anti-phospho-MBP,cloneP12(Cat.#05-429)
StorageandShippingInformation
Applications
ApplicationMAPKinase/ErkAssayKitisdesignedtomeasurethephosphotransferaseactivityofMAP(mitogen-activatedprotein)Kinaseinimmunoprecipitates&columnfractions.
KeyApplications
  • KinaseAssay
BIOLOGicalInformation
AnalytesAvailable
  • MAPKinase/Erk
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol
  • MAPK1
  • p40
  • PRKM2
  • MAPK2
  • PRKM1
  • p42-MAPK
  • p38
  • p41
  • ERK
  • ERK-2
  • ERT1
  • P42MAPK
  • p41mapk
  • ERK2
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
COFACTOR:Magnesium(Bysimilarity).
SIZE:360aminoacids;41390Da
SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。