4000-520-616
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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > 微孔/14-439 | MAP激酶1/Erk1蛋白,活性,10µg/14-439/10µ;gAlso可按目录提供250μg尺寸#
商品详细微孔/14-439 | MAP激酶1/Erk1蛋白,活性,10µg/14-439/10µ;gAlso可按目录提供250μg尺寸#
微孔/14-439 | MAP激酶1/Erk1蛋白,活性,10µg/14-439/10µ;gAlso可按目录提供250μg尺寸#
微孔/14-439 | MAP激酶1/Erk1蛋白,活性,10µg/14-439/10µ;gAlso可按目录提供250μg尺寸#
商品编号: 14-439
品牌: 密理博
市场价: ¥8020.00
美元价: 4812.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber14-439
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionMAPKinase1/Erk1Protein,active,10µg
OverviewRecombinant,full-length,humanMAPKinase1/Erk1containinganN-terminalGSTtag
ProductInformation
StorageandShippingInformation
StorageConditions1yearat-20°C
Applications
ApplicationActive,recombinant,full-length,humanMAPKinase1/Erk1containinganN-terminalGSTtag,foruseinKinaseAssays.
KeyApplications
  • KinaseAssay
BIOLOGicalInformation
SourceExpressedinE.coli
SpecificActivityForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol
  • MAPK1
  • p40
  • PRKM2
  • MAPK2
  • PRKM1
  • p42-MAPK
  • p38
  • p41
  • ERK
  • ERK-2
  • ERT1
  • P42MAPK
  • p41mapk
  • ERK2
ProteinTargetMAPK1
PurificationMethodPurifiedbyglutathione-agarose.ActivatedwithMEK1andrepurifiedonNi2+/NTAagarose
TargetSub-FamilyCMGC
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
COFACTOR:Magnesium(Bysimilarity).
SIZE:360aminoacids;41390Da
SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
MolecularWeight69.9kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。