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Millipore/MABS169 |抗ERK3抗体，克隆EP1720Y，兔| MABS169/MABS169/100µ；L
Millipore/MABS169 |抗ERK3抗体，克隆EP1720Y，兔| MABS169/MABS169/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABS169 |
| Description | Anti-ERK3Antibody,cloneEP1720Y,Rabbit|MABS169 |
| AlternateNames |
|
| BackgroundInformation | ERK3(Extracellularsignal-regulatedkinase3,MAPK6,p97MAPK)belongstotheSer/Thrproteinkinasefamilyandisamemberofthemitogen-activatedprotein(MAP)kinasesuperfamily.UnliketheothermembersoftheMAPKfamily,ERK3isamitogen-activatedproteinkinasehomologuethathasSEGmotifinsteadofconservedTXYmotifintheactivationloop(1).Also,unlikeERK1andERK2,itisubiquitouslyexpressedandlocalizedinthenucleusofproliferatingcells(2).Highlyunstable,ERK3isconstitutivelydegradedduringubiquitin-proteasomepathwayofproliferatingcells(3).ERK3hasbeenlinkedtophosphorylationMAP2andasapossIBLeregulatorduringcelldifferentiation(4). |
| ProductInformation | |
|---|---|
| Format | DilutedCultureSupernatant |
| Control |
|
| Presentation | RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtohumanERK3attheN-terminus. |
| Epitope | N-terminus |
| Clone | EP1720Y |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesERK3attheN-terminus. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Phosphorylatesmicrotubule-associatedprotein2(MAP2).MaypromoteentryinthecellcycleBysimilarity. CATALYTICACTIVITY:ATP+aprotein=ADP+aphosphoprotein. COFACTOR:MagnesiumBysimilarity. ENZYMEREGULATION:ActivatedbythreonineandtyrosinephosphorylationBysimilarity. TISSUESPECIFICITYHighestexpressionintheskeletalmuscle,followedbythebrain.Alsofoundinheart,placenta,lung,liver,pancreas,kidneyandskinfibroblasts. DOMAIN:TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-626andTyr-628,whichactivatestheenzymeBysimilarity. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily. Contains1proteinkinasedomain. |
| MolecularWeight | ~105kDaobserved |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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