微孔/ABS44 |抗MAPK 1/2抗体/ABS44/100µ；G
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABS44 |
| Replaces | 06-182 |
| Description | Anti-MAPK1/2Antibody |
| AlternateNames |
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| BackgroundInformation | Mitogen-activatedproteinkinase3(EC2.7.11.24;UniProtP21708;alsoknownasERK-1,ERT2,Extracellularsignal-regulatedkinase1,Insulin-stimulatedMAP2kinase,MAPkinase3,MAPkinaseisoformp44,MAPK3,Microtubule-associatedprotein2kinase,MNK1,p44-ERK1,p44-MAPK)isencodedbytheMapk3(alsoknownasErk1,Prkm3)gene(GeneID50689)inratspecies.ERK1(a.k.a.MAPK3)andERK2(a.k.a.MAPK1orMAPK2)arerelatedserine/threoninekinasesoftheRas-Raf-MEK-ERKsignalingpathway.ERK1/2areactivatedbyMEK1/2-catalyzedphosphorylationattheirconservedThr-Glu-Tyr(TEY)dualphosphorylationmotif,firstattheTyrresidue(human/ratERK1Tyr204/Tyr203,human/ratERK2Tyr187/Tyr183)andthenattheThrresidue(human/ratERK1Thr202/Thr201,human/ratERK2Thr185/Thr181).ERK1/2areproline-directedkinasesthatpreferentiallycatalyzethephosphorylationofPro-Xxx-Ser/Thr-Prosequencemotifinhundredsofcytoplasmicandnuclearsubstrates,includingtranscriptionfactorssuchasEts,Elk,andc-Fos.Besidesthisprimarystructurerequirement,manyERK1/2substratespossessaD-dockingsiteand/oranF-dockingsite.Avarietyofscaffoldproteins,includingKSR1/2,IQGAP1,MP1,andβ-Arrestin1/2,alsoparticipateintheregulationofERK1/2MAPkinasecascade.Ras-Raf-MEK-ERKsignalingactivityisupregulatedinaboutone-thirdofallhumancancers,andtargetedinhibitionagainstcomponentsofthissignalingpathwayrepresentsapopularanticancerstrategy. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtotheC-terminalsequenceofratMAPK3(ERK-1). |
| Epitope | C-terminal |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesMAPK3/MAPK1(ERK1/ERK2)C-terminalsequence. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Reactswithhuman,mouse,andrat.Expectedtoreactwithbovineandcaninebasedon94%sequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | ProteinApurfied. |
| UniProtNumber | |
| MolecularWeight | ~44/42kDaobserved.41.26/36.30kDa(humanMAPK1isoform1/2),41.14kDa(ratMAPK1),41.14kDa(mouseMAPK1),43.00/38.14kDa(humanMAPK3isoform1/2),42.95/45.64kDa(ratMAPK3isoform1/2),42.93kDa(mouseMAPK3)calculated(Met1removed).TargetsequenceisnotpresentinhumanMAPK3splicedisoform3(ERK1b). |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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