微孔/ABE257 |抗RAD51抗体/ABE257/100µ；L
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABE257 |
| Replaces | MABE515 |
| Description | Anti-RAD51Antibody |
| AlternateNames |
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| BackgroundInformation | RAD51isessentialforhomologousrecombinationofDNAduringrepairofdouble-strandbreaks.TheN-terminusofRAD51functionstobindDNAandpromotehomologouspairingandstrandexchangewithinaregularnucleoproteinfilament.Inyeast,theRad51familyofrelatedproteinsalsoincludesRad55,Rad57,andDmc1.Inmammaliancells,sevengenesinthisfamilyhavebeenidentified(HsRAD51,XRCC2,XRCC3,RAD51B/hREC2andHsDMC1,RAD51C,andRAD51D).RAD51ispredominantlyexpressedinthetestisandthymusbutcanalsobefoundinthesmallintestine,placenta,colon,pancreasandovaries. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Histidine-taggedrecombinantproteincorrespondingtohumanRAD51. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| SpeciesReactivity |
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| SpeciesReactivityNote | DemonstratedtoreactwithHuman,Mouse,andRat.Otherhomologies:Bovine,Equine,andCanine(99%sequencehomology). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheRAD51proteinfamily.RAD51familymembersarehighlysimilartobacterialRecAandSaccharomycescerevisiaeRad51,andareknowntobeinvolvedinthehomologousrecombinationandrepairofDNA.ThisproteincaninteractwiththessDNA-bindingproteinRPAandRAD52,anditisthoughttoplayrolesinhomologouspairingandstrandtransferofDNA.ThisproteinisalsofoundtointeractwithBRCA1andBRCA2,whichmaybeimportantforthecellularresponsetoDNAdamage.BRCA2isshowntoregulateboththeintracellularlocalizationandDNA-bindingABIlityofthisprotein.LossofthesecontrolsfollowingBRCA2inactivationmaybeakeyeventleADIngtogenomicinstabilityandtumOrigenesis.Multipletranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq]. |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:MayparticipateinacommonDNAdamageresponsepathwayassociatedwiththeactivationofhomologousrecombinationanddouble-strandbreakrepair.BindstosingleanddoublestrandedDNAandexhibitsDNA-dependentATPaseactivity.UnderwindsduplexDNAandformshelicalnucleoproteinfilaments.PlaysaroleinregulatingmitochondrialDNAcopynumberunderconditionsofoxidativestressinthepresenceofRAD51CandXRCC3. SUBUNITSTRUCTURE:InteractswithBRCA1,BRCA2andeitherdirectlyorindirectlywithp53.InteractswithXRCC3,RAD54LandRAD54B.PartofacomplexwithRAD51CandRAD51B.InteractswithRAD51AP1andRAD51AP2.InteractswithCHEK1/CHK1,andthismayrequirepriorphosphorylationofCHEK1.InteractswiththeMND1-PSMC3IPheterodimer(Bysimilarity).InteractswithOBFC2B.InteractswithRPA1.InteractswithPALB2.InteractswithSWI5/C9orf119,andatlowerlevelwithSFR1/MEIR5. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Cytoplasm›perinuclearregion.Mitochondrionmatrix.Note:ColocalizeswithRAD51AP1tomultiplenuclearfociuponinductionofDNAdamage.DNAdamageinducesanincreaseinnuclearlevels. TISSUESPECIFICITY:Highlyexpressedintestisandthymus,followedbysmallintestine,placenta,colon,pancreasandovary.Weaklyexpressedinbreast. INDUCTION:Stress-inducedincreaseinthemitochondriallevelsisseen. PTM:Phosphorylated.PhosphorylationofThr-309byCHEK1/CHK1mayenhanceassociationwithchromatinatsitesofDNAdamageandpromoteDNArepairbyhomologousrecombination. INVOLVEMENTINDISEASE:DefectsinRAD51areacauseofsusceptibilitytobreastcancer(BC)[MIM:114480].Acommonmalignancyoriginatingfrombreastepithelialtissue.Breastneoplasmscanbedistinguishedbytheirhistologicpattern.Invasiveductalcarcinomaisbyfarthemostcommontype.Breastcancerisetiologicallyandgeneticallyheterogeneous.Importantgeneticfactorshavebeenindicatedbyfamilialoccurrenceandbilateralinvolvement.Mutationsatmorethanonelocuscanbeinvolvedindifferentfamiliesoreveninthesamecase.Ref.28 SEQUENCESIMILARITIES:BelongstotheRecAfamily.RAD51subfamily. Contains1HhHdomain. |
| MolecularWeight | ~37kDaobserved.Twoisoforms(isoform1at37kDaandisoform2at26kDa)producedasaresultofalternativesplicingareknowntoexist:. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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