密理博/05-530 |抗Rad51抗体，克隆3C10/05-530/200µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-530 |
| Replaces | MABE515 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Rad51Antibody,clone3C10 |
| BackgroundInformation | Rad51issimilartoRecA,bothbiochemicallyandstructurally.Itpromoteshomologouspairingandstrandexchangewithinaregularnucleoproteinfilament.Inyeast,theRad51familyofrelatedproteinsalsoincludesRad55,Rad57,andDmc1.Inmammaliancells,sevengenesinthisfamilyhavebeenidentified(HsRAD51,XRCC2,XRCC3,RAD51B/hREC2andHsDMC1,RAD51C,andRAD51D).RecentstudiessuggestedthatRad51isinvolvednotonlyinhomologousrecombinationbutalsoincellproliferationregulation. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| Applications | |
|---|---|
| Application | DetectRad51withAnti-Rad51Antibody,clone3C10(MouseMonoclonalAntibody),thathasbeenshowntoworkinIP&WB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | FulllengthhumanRad51 |
| Clone | clone3C10 |
| Host | Mouse |
| Specificity | Rad51;slightcross-reactivitywithDMC1 |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheRAD51proteinfamily.RAD51familymembersarehighlysimilartobacterialRecAandSaccharomycescerevisiaeRad51,andareknowntobeinvolvedinthehomologousrecombinationandrepairofDNA.ThisproteincaninteractwiththessDNA-bindingproteinRPAandRAD52,anditisthoughttoplayrolesinhomologouspairingandstrandtransferofDNA.ThisproteinisalsofoundtointeractwithBRCA1andBRCA2,whichmaybeimportantforthecellularresponsetoDNAdamage.BRCA2isshowntoregulateboththeintracellularlocalizationandDNA-bindingABIlityofthisprotein.LossofthesecontrolsfollowingBRCA2inactivationmaybeakeyeventleADIngtogenomicinstabilityandtumOrigenesis.Twoalternativelysplicedtranscriptvariantsofthisgene,whichencodedistinctproteins,havebeenreported.TranscriptvariantsutilizingalternativepolyAsignalsexist. |
| GeneSymbol |
|
| PurificationMethod | ProteinGChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q06609#MayparticipateinacommonDNAdamageresponsepathwayassociatedwiththeactivationofhomologousrecombinationanddouble-strandbreakrepair.BindstosingleanddoublestrandedDNAandexhibitsDNA-dependentATPaseactivity.UnderwindsduplexDNAandformshelicalnucleoproteinfilaments. SIZE:339aminoacids;36966Da SUBUNIT:InteractswithBRCA1,BRCA2andeitherdirectlyorindirectlywithp53.InteractswithXRCC3,RAD54LandRAD54B.PartofacomplexwithRAD51CandRAD51B.InteractswithRAD51AP1.InteractswithCHEK1/CHK1,andthismayrequirepriorphosphorylationofCHEK1. SUBCELLULARLOCATION:Nucleus.Note=ColocalizeswithRAD51AP1tomultiplenuclearfociuponinductionofDNAdamage. TISSUESPECIFICITY:Highlyexpressedintestisandthymus,followedbysmallintestine,placenta,colon,pancreasandovary.Weaklyexpressedinbreast. PTM:Phosphorylated.PhosphorylationofThr-309byCHEK1/CHK1mayenhanceassociationwithchromatinatsitesofDNAdamageandpromoteDNArepairbyhomologousrecombination.DISEASE:SwissProt:Q06609#DefectsinRAD51areassociatedwithbreastcancer(BC)[MIM:114480]. SIMILARITY:SwissProt:Q06609##BelongstotherecAfamily.RAD51subfamily.&Contains1HhHdomain. |
| MolecularWeight | 37kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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