Millipore/05-347 |抗PCNA抗体，克隆PC10/05-347/100µ；G
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-347 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-PCNAAntibody,clonePC10 |
| BackgroundInformation | Expressionofproliferatingcellnuclearantigen(PCNA),cyclinorpolymerasedeltaauxiliaryproteiniselevatedinthenucleusduringlateG1phaseimmediatelybeforetheonsetofDNAsynthesis,becomingmaximalduringS-phaseanddecliningduringG2andMphases.PCNA/cyclinmayactasanauxiliaryproteinofDNApolymerase-deltatoplayafundamentalroleintheinitiationofcellproliferation.Anti-PCNAreactswithPCNAatthemolecularweightof36kDaonwesternblot. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ProteinApurifiedmouseimmunoglobulininPBScontaining1mg/mLBSAand10mMSodiumAzide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| Applications | |
|---|---|
| Application | DetectPCNAwithAnti-PCNAAntibody,clonePC10(MouseMonoclonalAntibody),thathasbeenshowntoworkinWB,ICC&IHC. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantratPCNA |
| Clone | clonePC10 |
| Host | Mouse |
| Specificity | PCNA |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisfoundinthenucleusandisacofactorofDNApolymerasedelta.TheencodedproteinactsasahomotrimerandhelpsincreasetheprocessivityofleADIngstrandsynthesisduringDNAreplication.InresponsetoDNAdamage,thisproteinisubiquitinatedandisinvolvedintheRAD6-dependentDNArepairpathway.Twotranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.Pseudogenesofthisgenehavebeendescribedonchromosome4andontheXchromosome. |
| GeneSymbol |
|
| PurificationMethod | Concentratedculturesupernatant |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P12004#ThisproteinisanauxiliaryproteinofDNApolymerasedeltaandisinvolvedinthecontrolofeukaryoticDNAreplicationbyincreasingthepolymerase"sprocessibilityduringelongationoftheleadingstrand. SIZE:261aminoacids;28769Da SUBUNIT:Homotrimer.InteractswithKCTD10(Bysimilarity).Formsacomplexwithactivator1heteropentamerinthepresenceofATP.InteractswithPOLH,POLK,DNMT1,ERCC5/XPG,FEN1,CDC6,APEX2andPOLDIP2.InteractswithEXO1andSHPRH. SUBCELLULARLOCATION:Nucleus. PTM:Uponmethylmethanesulfonate-inducedDNAdamage,mono-ubiquitinatedbytheUBE2B-RAD18complexonLys-164.Thisinducesnon-canonicalpoly-ubiquitinationonLys-164through"Lys-63"linkageofubiquitinmoietiesbytheE2complexUBE2N-UBE2V2andtheE3ligaseSHPRH,whihisrequiredforDNArepair. DISEASE:SwissProt:P12004#Antibodiesarepresentinserafrompatientswithsystemiclupuserythematosus. SIMILARITY:SwissProt:P12004##BelongstothePCNAfamily. |
| MolecularWeight | 36kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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