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Millipore/AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop/AB1847/100 µg
Millipore/AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop/AB1847/100 µg
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1847 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-C-X-CChemokineReceptor4Antibody,extracellularloop |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedIgGinPBScontaining0.02%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Canberefrigeratedat2-8°Cinundilutedaliquotsforupto12monthsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | ExtracellularlooppeptideofhumanCXCR4(Bersonetal.1996;Leotscheretal.1994). |
| Epitope | extracellularloop |
| Host | Rabbit |
| Specificity | SomeGprotein-coupledreceptorsincludingCCR5,CXCR4,CCR3,CCR2bandCCR8inthechemokinereceptorfamily,andfournewhumanmoleculesGPR15,STRL33,GPR1andV28wererecentlyidentifiedasHIVcoreceptors(Nimitrov1997).Amongthem,CXCR4(fusin,LESTRorHUMSTR)isaprinciplecoreceptorforT-celltropicstrainsofHIV-1fusionandentryofhumanwhitebloodcells(Fengetal.1996;Bersonetal.1996).CXCR4isalsorequiredfortheinfectionbydual-tropicstrainsofHIV-1andmediatesCD-4independentinfectionbyHIV-2(Doranzetal.1996;Endresetal.1996).Thea-chemokineSDF-1istheligandforCXCR4andpreventsinfectionbyT-tropicHIV-1(Bleuletal.1996;Oberlinetal.1996).CXCR4associateswiththesurfaceCD4-gp120complexbeforeHIVenterstargetcells(Laphametal.1996).CXCR4messengerRNAlevelscorrelatedwithHIV-1permissivenessindiversehumancelltypes(Fengetal.1996).AntibodiestoCXCR4blockHIV-1andHIV-2fusionandinfectionofhumantargetcells(Fengetal.1996;Endresetal.1996;Brelotetal.1997).Theamino-terminaldomainandthesecondextracellularloopofCXCR4serveasHIVbindingsites(Brelotetal.1997;Luetal.1997). |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus. SIZE:352aminoacids;39746Da SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat. SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested. DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity. PTM:Sulfated. DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis. SIMILARITY:BelongstotheG-proteincoupledreceptor1family. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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