密理博/AB4251 |抗CXC趋化因子受体4抗体，NT，细胞外/AB4251/50µ；G
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB4251 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-CXCChemokineReceptor4Antibody,NT,extracellular |
| AlternateNames |
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| BackgroundInformation | CXCR4isachemokinereceptorinvolvedinorganvascularization,neuronalcellmigration,andpatterningofthecentralnervoussystemduringdevelopment.Itbindsstromalcell-derivedfactor1(SDF1)andmediatesmigrationofrestingleukocytesandisuniqueinhominghematopoieticProgenitorstobonemarrow.ThesepropertiessuggestthatCXCR4isinvolvedintumorcellmigrationandlocaltumorinvasion.ItisalsoanHIV-1fusionco-factorthatallowsHIV-1invasionindiversehumancelltypes.CXCR4hastwoisoformsthatareproducedbyalternativesplicingandhasbeenreportedtobeexpressedincellsoftheimmuneandcentralnervoussystems.Itishighlyexpressedinbrainandheart,andinwhitebloodcells,vascularendothelialcells,andumbilicalcordendothelialcells.Inbraintumors,CXCR4isexpressedinregionsofangiogenesisanddegenerative,necrotic,andmicrocysticchanges(Rempeletal.,2000).ESTshavebeenisolatedfromawidevarietyoftissuelibraries,particularlyuterus,kidney,lung,tonsil,andbrain. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Peptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoasequencewithintheN-terminalextracellulardomainofhumanCXCR4.Theimmunogenhas93%homologywithmouseandrat. |
| Epitope | N-terminal,extracellular |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizeshumanCXCR4.ThespecificityofthisantibodyhasbeenconfirmedbyIHCstainingofcardiacmyocytesinhumanheart. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus. SIZE:352aminoacids;39746Da SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat. SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested. DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity. PTM:Sulfated. DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis. SIMILARITY:BelongstotheG-proteincoupledreceptor1family. |
| PhysicochemicalInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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