Millipore/AB4250 |抗CXC趋化因子受体3抗体,CT结构域/AB4250/50µ;G
市场价:
¥7180.00
美元价:
4308.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | AB4250 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-CXCChemokineReceptor3Antibody,CTdomain |
AlternateNames |
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BackgroundInformation | CXCR3,achemokinereceptor,ishighlysimilartotheinterleukin8BreceptorandhasbeenshowntomediaterecruitmentofTcellstositesofinflammationandretentionofT-cellsintheinflamedCNS.CXCR3hasbeensuggestedtobetheprincipalinflammatorychemokinereceptorinvolvedinintrathecalaccumulationofT-cellsinmultiplesclerosisanddiabetes.ItisexpressedonmalignantBcellsinchroniclymphoproliferativedisorders(Jonesetal.,2000).Analternativelysplicedisoform,CXCR3B,hasrecentlybeenidentified(Lasagnietal.,2003).CXCR3expressionhasbeendocumentedinthebrain,lymphoidandotherperipheraltissues,andindiseasesincludingatherosclerosis,Alzheimer"s,multiplesclerosis,rheumatoidarthritis,lymphomas,asthma,neoplasms,leukemia,andinflammatoryconditionsofvariousorgans. |
ProductInformation | |
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Format | AffinityPurified |
Presentation | Peptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide |
StorageandShippingInformation | |
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StorageConditions | Maintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles. |
BIOLOGicalInformation | |
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Immunogen | SyntheticpeptidecorrespondingtoasequencewithintheC-terminaldomainofhumanCXCR3.Theimmunogenhas82%homologywithratandmouse. |
Epitope | C-terminaldomain |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizeshumanCXCR3.ThespecificityofthisantibodyhasbeenevaluatedbyIHCstainingofhumantonsil. |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | CD183isaGprotein-coupledreceptorwithselectivityforthreechemokines,termedIP10(interferon-g-inducIBLe10kDaprotein),Mig(monokineinducedbyinterferon-g)andI-TAC(interferon-inducibleTcella-chemoattractant).IP10,MigandI-TACbelongtothestructuralsubfamilyofCXCchemokines,inwhichasingleaminoacidresidueseparatesthefirsttwooffourhighlyconservedCysresidues.Historically,CD183isthethirdCXCchemokinereceptordiscoveredand,therefore,commonlydesignatedasCXCR3.BindingofchemokinestoCD183inducescellularresponsesthatareinvolvedinleukocytetraffic,mostnotablyintegrinactivation,cytoskeletalchangesandchemotacticmigration.InhibitionbyBordetellapertussistoxinsuggeststhatheterotrimericGproteinoftheGi-subclasscoupletoCD183.Signaltransductionhasnotbeenfurtheranalyzedbutmayincludethesameenzymesthatwereidentifiedinthesignalingcascadeinducedbyotherchemokinereceptors.Asaconsequenceofchemokine-inducedcellulardesensitization(phosphorylation-dependentreceptorinternalization),cellularresponsesaretypicallyrapidandshortinduration.Cellularresponsivenessisrestoredafterdephosphorylationofintracellularreceptorsandsubsequentrecyclingtothecellsurface.AhallmarkofCD183isitsprominentexpressionininvitroculturedeffector/memoryTcells,andinTcellspresentinmanytypesofinflamedtissues.Inaddition,IP10,MigandI-TACarecommonlyproducedbylocalcellsininflammatorylesion,suggestingthatCD183anditschemokinesparticipateintherecruitmentofinflammatorycells.Therefore,CD183isatargetforthedevelopmentofsmallmolecularweightantagoNISTs,whichmaybeusedinthetreatmentofdiverseinflammatorydiseases. |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P49682#ReceptorforCXCL9,CXCL10andCXCL11andmediatestheproliferationofhumanmesangialcells(HMC).Isoform2isareceptorforCXCL4andalsomediatestheinhibitoryactivitiesofCXCL9,CXCL10andCXCL11onthegrowthofhumanmicrovascularendothelialcells(HMVEC).Isoform2mayplayaroleinangiogenesis.Isoform3mediatesactivityofCXCL11. SIZE:368aminoacids;40660Da SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Isoform1andisoform2aremainlyexpressedinheart,kidney,liverandskeletalmuscle.Isoform1isalsoexpressedinplacenta. SIMILARITY:SwissProt:P49682##BelongstotheG-proteincoupledreceptor1family. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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