Millipore/AB9610 | Anti-Olig-2 Antibody/AB9610/100 µL
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB9610 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Olig-2Antibody |
| AlternateNames |
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| BackgroundInformation | Olig2(oligodendrocytetranscriptionfactor2)isrequiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.ItcooperateswithOLIG1toestablishthepMNdomainoftheembryonicneuraltube.ItisanantagoNISTofV2interneuronandofNKX2-2-inducedV3interneurondevelopment.TherestrictedexpressionofOlig2inoligodendrocytesmakesAB9610anexcellentMarkerofoligodendrogliaandoligodendrogliomasindevelopmentandmaturesystems. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonal.Liquidin100mMGlycine,200mMTris,pH8.0. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantmouseOlig-2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Recognizesthe~32kDaOlig-2proteinbyWesternblot. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,ratandmouse.Otherspecieshavenotbeentested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesabasichelix-loop-helixtranscriptionfactorwhichisexpressedinoligodendroglialtumorsofthebrain.TheproteinisanessentialregulatorofventralneuroectodermalProgenitorcellfate.Thegeneisinvolvedinachromosomaltranslocationt(14;21)(q11.2;q22)associatedwithT-cellacutelymphoblasticleukemia.Itschromosomallocationiswithinaregionofchromosome21whichhasbeensuggestedtoplayaroleinlearningdeficitsassociatedwithDownsyndrome. |
| GeneSymbol |
|
| PurificationMethod | AmmoniumSulfatePrecipitation |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q13516#Requiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.CooperateswithOLIG1toestablishthepMNdomainoftheembryonicneuraltube.AntagonistofV2interneuronandofNKX2-2-inducedV3interneurondevelopment(Bysimilarity). SIZE:323aminoacids;32385Da SUBUNIT:InteractswithNKX2-2(Bysimilarity). SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity).Note=TheNLScontainedinthebHLHdomaincouldbemaskedinthenativeformandtranslocationtothenucleuscouldbemediatedbyinteractioneitherwithclassEbHLHpartnerproteinorwithNKX2-2(Bysimilarity). TISSUESPECIFICITY:Expressedinthebrain,inoligodendrocytes.Stronglyexpressedinoligodendrogliomas,whileexpressionisweaktomoderateinastrocytomas.Expressioninglioblastomashighlyvariable. DOMAIN:SwissProt:Q13516ThebHLHisessentialforinteractionwithNKX2-2(Bysimilarity).DISEASE:SwissProt:Q13516#AchromosomalaberrationinvolvingOLIG2maybeacauseofaformofT-cellacutelymphoblasticleukemia(T-ALL).Translocationt(14;21)(q11.2;q22)withTCRA. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.... |
| MolecularWeight | ~32kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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