密理博/07-606 |抗磷酸-JAK2（Tyr1007/1008）抗体/07-606/200µ；G
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-606 |
| Replaces | 04-1098 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-phospho-JAK2(Tyr1007/1008)Antibody |
| AlternateNames |
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| BackgroundInformation | JAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.Amongavarietyofsites,Tyrosines1007and1008aresitesoftrans-orautophosphorylationinvivoandininvitrokinasereactions. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | PurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%SodiumAzide,pH7.4. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | Anti-phospho-JAK2(Tyr1007/1008)Antibodydetectslevelofphospho-JAK2(Tyr1007/1008)&hasbeenpublished&validatedforuseinWB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacidssurroundingphosphotyrosines1007and1008ofhumanJAK2. |
| Epitope | Tyr1007/1008 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesphosphorylatedJAK2,Mr130kDa. |
| Isotype | IgG |
| SpeciesReactivity |
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| SpeciesReactivityNote | Humanandmouse.Predictedtocross-reactwithratbasedonsequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneproductisaproteintyrosinekinaseinvolvedinaspecificsubsetofcytokinereceptorsignalingpathways.Ithasbeenfoundtobeconstituitivelyassociatedwiththeprolactinreceptorandisrequiredforresponsestogammainterferon.Micethatdonotexpressanactiveproteinforthisgeneexhibitembryoniclethalityassociatedwiththeabsenceofdefinitiveerythropoiesis. |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:O60674#Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction. SIZE:1132aminoacids;130674Da SUBUNIT:InteractswithSIRPA(Bysimilarity).InteractswithIL23R,SKB1andSTAM2. SUBCELLULARLOCATION:Intracytoplasmicmembrane;Peripheralmembraneprotein(Bysimilarity).Note=Whollyintracellular,possIBLymembraneassociated(Bysimilarity). TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode. DOMAIN:SwissProt:O60674Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomain(Bysimilarity),whilethepresenceofslightdifferencessuggestadifferentrolefordomain1. DISEASE:SwissProt:O60674#ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.&DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.&DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.&DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.&DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.&DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment. SIMILARITY:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.&Contains1FERMdomain.&Contains1proteinkinasedomain.&Contains1SH2domain. |
| MolecularWeight | 130kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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