Millipore/06-1310 | Anti-JAK2 Antibody/06-1310/100 µg
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-1310 |
| Description | Anti-JAK2Antibody |
| AlternateNames |
|
| BackgroundInformation | TheJanusfamilyoftyrosinekinases(JAK)includesJAK1,JAK2,JAK3andTyk2.Thisfamilyassociateswithavarietyofcytokinereceptorsandisactivatedbyligandbinding.Uponligandbindingtocytokinereceptors,JAKsphosphorylatethemselvesandtheirassociatedreceptors.ThisprovidesmultiplebindingsitesforsignalingproteinscontainingSH2orotherphospho-tyrosine-bindingdomains,includingSTATs,Shc,insulinreceptorsubstratesandFAK. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtotheproteinkinase1domainofmouseJAK2. |
| Epitope | Proteinkinase1domain |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Thisantibodyrecognizestheproteinkinase1domainofJAK2. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction(Bysimilarity).Playsaroleinleptinsignalingandcontrolofbodyweight. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNITSTRUCTURE:InteractswithIL23R,SKB1andSTAM2(Bysimilarity).InteractswithSIRPAandSH2B1. SUBCELLULARLOCATION:Endomembranesystem;PeripheralmembraneproteinBysimilarity.Note:Whollyintracellular,possIBLymembraneassociated(Bysimilarity). DOMAIN:Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomain(Bysimilarity),whilethepresenceofslightdifferencessuggestadifferentrolefordomain1. PTM:Leptinpromotesphosphorylationontyrosineresidues,includingphosphorylationonTyr-813. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily. Contains1FERMdomain. Contains1proteinkinasedomain. Contains1SH2domain. |
| MolecularWeight | ~130kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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