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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/04-001 | Anti-JAK2 Antibody, clone 8E10.2/04-001/100 µg
商品详细Millipore/04-001 | Anti-JAK2 Antibody, clone 8E10.2/04-001/100 µg
Millipore/04-001 | Anti-JAK2 Antibody, clone 8E10.2/04-001/100 µg
Millipore/04-001 | Anti-JAK2 Antibody, clone 8E10.2/04-001/100 µg
商品编号: 04-001
品牌: 密理博
市场价: ¥5740.00
美元价: 3444.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber04-001
TradeName
  • Upstate
DescriptionAnti-JAK2Antibody,clone8E10.2
AlternateNames
  • Januskinase2
  • Tyrosinekinase
BackgroundInformationJAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerizesandtranslocatestothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.
ProductInformation
FormatPurified
Control
  • L6celllysate
PresentationPurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationAnti-JAK2Antibody,clone8E10.2detectslevelofJAK2&hasbeenpublished&validatedforuseinWB,IH(P).
KeyApplications
  • WesternBlotting
  • Immunohistochemistry(Paraffin)
ApplicationNotesWesternBlotAnalysis:0.5-1μg/mLofthislotwasusedtodetectJak2inL6celllysates.

Immunohistochemistry(Paraffin):
Apreviouslotofthisantibodywasusedinimmunohistochemistry(paraffin)stainingwitheptioperetrieval:HumanCancerArray.
BIOLOGicalInformation
ImmunogenKLH-conjugatedlinearpeptide.
Clone8E10.2
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityThisantibodyrecognizesJak2.
IsotypeIgG1κ
SpeciesReactivity
  • Human
  • Mouse
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneproductisaproteintyrosinekinaseinvolvedinaspecificsubsetofcytokinereceptorsignalingpathways.Ithasbeenfoundtobeconstituitivelyassociatedwiththeprolactinreceptorandisrequiredforresponsestogammainterferon.Micethatdonotexpressanactiveproteinforthisgeneexhibitembryoniclethalityassociatedwiththeabsenceofdefinitiveerythropoiesis.[providedbyRefSeq]
GeneSymbol
  • JAK2
  • JAK-2
PurificationMethodProteinGPurified
UniProtNumber
MolecularWeight130kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。