Millipore/ABN78 | Anti-NeuN Antibody (rabbit)/ABN78/100 µg
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN78 |
| Description | Anti-NeuNAntibody(rabbit) |
| AlternateNames |
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| BackgroundInformation | RNAbindingproteinfox-1homolog3(UniProtQ8BIF2;alsoknownasFox-1homologC,Fox-3,Hexaribonucleotide-bindingprotein3,NeuN,Neuronalnuclei)isencodedbytheRbfox3(alsoknownasD11Bwg0517e,Hrnbp3)gene(GeneID52897)inmurinespecies.TheRNA-bindingFox(Rbfox)familyofsplicingfactorsiscomprisedofthreemembers,Rbfox1(Fox-1orA2BP1),Rbfox2(Fox-2orRBM9),andRbfox3(Fox-3,HRNBP3orNeuN).Rbfoxproteinsregulatesplicingofmanyneuronaltranscripts(pre-mRNAs)bybindingthesequence(U)GCAUGinintronsflankingalternativeexons.A(U)GCAUGmotifthatliesdownstreamofthealternativeexongenerallypromotesRbfox-dependentexoninclusion,whereasanupstreammotifwillusuallyrepressexoninclusion.OriginallycharacterizedasaMarkerofpost-mitoticneuronsandnamedneuronalnuclei(NeuN),Rbfox3playsaroleinpromotingneuronaldifferentiationthroughalternativesplicingofNumbpre-mRNAduringbraindevelopment.Rbfox3-knockoutinmiceisreportedtoresultindefectivehippocampalgeneexpression,defectsinsynaptictransmissionandplasticityinthedentategyrus,aswellasincreasedseizuresusceptibilityanddecreasedanxiety-relatedbehaviors.Likewise,humanRBFOX3genemutationshavebeenlinkedtoneurodevelopmentaldelay,cognitiveimpairments,autisticfeatures,andepilepsy. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GST-taggedrecombinantmouseNeuNN-terrminalfragment. |
| Epitope | N-terminus |
| Concentration | Pleaserefertolotspecificdatasheet. |
| Host | Rabbit |
| Specificity | ThisrabbitpolyclonalantibodytargetsNeuNN-terminalregionthatendsatthestartofRNArecognitionmotif(RRM).Targetregionispresentinallhuman,mouse,andratsplicedisoformsreportedbyUniProt(A6NFN3,Q8BIF2,D4A2H6,A0A0G2K2J4). |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse,Rat,Snail. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| MolecularWeight | ~48/42kDaobserved.33.87/35.12kDa(humanisoform1/2),40.61/39.05/35.64/34.07/35.63kDa(mouseisoform1/2/3/4/5),40.59kDa(rat;UniProtD4A2H6),34.05kDa(rat;UniProtA0A0G2K2J4)calculated.Uncharacterizedbandsmaybeobservedinsomelysate(s). |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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