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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/05-785 |抗CD3ε抗体,克隆APA1/1/05-785/200µ;G
商品详细Millipore/05-785 |抗CD3ε抗体,克隆APA1/1/05-785/200µ;G
Millipore/05-785 |抗CD3ε抗体,克隆APA1/1/05-785/200µ;G
Millipore/05-785 |抗CD3ε抗体,克隆APA1/1/05-785/200µ;G
商品编号: 05-785
品牌: 密理博
市场价: ¥5540.00
美元价: 3324.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber05-785
Replaces04-460
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionAnti-CD3εAntibody,cloneAPA1/1
ProductInformation
FormatPurified
Presentation0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide
StorageandShippingInformation
StorageConditions1yearat2-8°Cfromdateofshipment.
Applications
ApplicationDetectCD3εusingthisAnti-CD3εAntibody,cloneAPA1/1validatedforuseinFC,IP,WB&IC.
KeyApplications
  • FlowCytometry
  • Immunoprecipitation
  • WesternBlotting
  • Immunocytochemistry
ApplicationNotesCloneAPA1/1hasbeendemonstratedtorecognizeasiteonCD3&epsilon:thatisexposeduponengagementoftheT-CellReceptorcomplex.ExposureofthisneoepitopeprecedesCD3phosphorylationandrecruitmentandactivationofZAP-70,whichinitiatesthesignalingcascadeproducedbyT-cellactivation.Assuch,cloneAPA1/1providestheearliestknownMarkerforT-CellReceptorengagement,andthusT-cellactivation.
BIOLOGicalInformation
ImmunogenPurifiedhumanCD3epsilon
CloneAPA1/1
HostMouse
SpecificityCDε
IsotypeIgG1
SpeciesReactivity
  • Human
  • Mouse
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneistheCD3-epsilonpolypeptide,whichtogetherwithCD3-gamma,-deltaand-zeta,andtheT-cellreceptoralpha/betaandgamma/deltaheterodimers,formstheT-cellreceptor-CD3complex.Thiscomplexplaysanimportantroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.Thegenesencodingtheepsilon,gammaanddeltapolypeptidesarelocatedinthesameclusteronchromosome11.TheepsilonpolypeptideplaysanessentialroleinT-celldevelopment.Defectsinthisgenecauseimmunodeficiency.ThisgenehasalsobeenlinkedtoasusceptibilitytotypeIdiabetesinwomen.
GeneSymbol
  • CD3E
  • T3E
  • TCRE
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P07766#TheCD3complexmediatessignaltransduction.
SIZE:207aminoacids;23147Da
SUBUNIT:TheTCR/CD3complexofT-lymphocytesconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimercoexpressedatthecellsurfacewiththeinvariantsubunitsofCD3labeledgamma,delta,epsilon,zeta,andeta.
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
SIMILARITY:SwissProt:P07766##Contains1Ig-like(immunoglobulin-like)domain.&Contains1ITAMdomain.
MolecularWeight~23kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。