Millipore/05-785 |抗CD3ε抗体,克隆APA1/1/05-785/200µ;G
市场价:
¥5540.00
美元价:
3324.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-785 |
| Replaces | 04-460 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-CD3εAntibody,cloneAPA1/1 |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 1yearat2-8°Cfromdateofshipment. |
| Applications | |
|---|---|
| Application | DetectCD3εusingthisAnti-CD3εAntibody,cloneAPA1/1validatedforuseinFC,IP,WB&IC. |
| KeyApplications |
|
| ApplicationNotes | CloneAPA1/1hasbeendemonstratedtorecognizeasiteonCD3&epsilon:thatisexposeduponengagementoftheT-CellReceptorcomplex.ExposureofthisneoepitopeprecedesCD3phosphorylationandrecruitmentandactivationofZAP-70,whichinitiatesthesignalingcascadeproducedbyT-cellactivation.Assuch,cloneAPA1/1providestheearliestknownMarkerforT-CellReceptorengagement,andthusT-cellactivation. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedhumanCD3epsilon |
| Clone | APA1/1 |
| Host | Mouse |
| Specificity | CDε |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneistheCD3-epsilonpolypeptide,whichtogetherwithCD3-gamma,-deltaand-zeta,andtheT-cellreceptoralpha/betaandgamma/deltaheterodimers,formstheT-cellreceptor-CD3complex.Thiscomplexplaysanimportantroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.Thegenesencodingtheepsilon,gammaanddeltapolypeptidesarelocatedinthesameclusteronchromosome11.TheepsilonpolypeptideplaysanessentialroleinT-celldevelopment.Defectsinthisgenecauseimmunodeficiency.ThisgenehasalsobeenlinkedtoasusceptibilitytotypeIdiabetesinwomen. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07766#TheCD3complexmediatessignaltransduction. SIZE:207aminoacids;23147Da SUBUNIT:TheTCR/CD3complexofT-lymphocytesconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimercoexpressedatthecellsurfacewiththeinvariantsubunitsofCD3labeledgamma,delta,epsilon,zeta,andeta. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P07766##Contains1Ig-like(immunoglobulin-like)domain.&Contains1ITAMdomain. |
| MolecularWeight | ~23kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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