微孔/ECM460 |αVβ3/PECAM研究试剂盒/ECM460/1试剂盒
市场价：
¥9540.00
美元价：
5724.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ECM460 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | αVβ3/PECAMInvestigatorKit |
| Overview | ChemiconInvestigatorKitsforIntegrinResearchareacost-effectivesourceofreagentsforallinvestigatorsinvolvedwiththisrapidlyexpandingfieldofstudy.ThealphaVbeta3/PECAMIntegrinInvestigatorKitisdesignedforresearchfocusedonthepresenceofthehumanalphaVbeta3integrinsubunitonPECAM-1[CD31]expressingcells.ThealphaVbeta3/PECAMIntegrinInvestigatorKitcontains100mgeachofCy5-conjugatedmouseanti-integrinalphaVbeta3andFluorescein-conjugatedmouseanti-PECAM-1[CD31]monoclonalantibodies. Integrinsbelongtoalargefamilyofcellsurfaceproteinscommonlyreferredtoasglycoproteins.Integrinsarecomposedofnoncovalentlyassociatedalphaandbetasubunitswhichmakeupheterodimers:thelargertermedalphachainandthesmallerbetachain.Atleast16alphasubunitsand8betasubunitsareexpressed,whichcangiveriseto22differentintegrins.Integrinsarethoughttoplaycriticalrolesincellmigration,differentiation,andsurvival.Thereisnowconsiderableevidencethatthesetransmembranereceptorsplayanimportantroleintheregulationofgeneexpressionandsignaltransduction.Excellentreviewsofintegrinstructure,function,andligandspecificitymaybefoundin:Hynes,R.1992.Cell69:11-25;Kramer,R.1993."IntegrinStructureandLigandSpecificityinCell-MatrixInteractions"inMolecularandCellularAspectsofBasementMembranes.AcademicPress. Thereagentsinthiskitarenotapplicationspecificbutrathermaybeusedinavarietyofprocedures,dependingupontheneedsoftheindividualinvestigator.ThecombinationofCy5andFluoresceinlabelspermitssimultaneouslabelingofIntegrinalphaVbeta3andPECAMinflowcytometryorimmunofluorescence. Thiskitandreagentsisnotintendedforuseinadiagnosticorclinicalsetting. |
| ProductInformation | |
|---|---|
| Components |
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| Presentation | 100μgeachofmonoclonalstoalphaVbeta3andPECAM,labeledwithCY5andFITC,respectively. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Storeantibodiesat2-8°C.Protectfromlight. ImportantNote:Duetothesmallvolumescontainedwithinthekit,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidentrappedinthecontainer"scapduringshipment. |
| Applications | |
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| BIOLOGicalInformation | |
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| SpeciesReactivity |
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| EntrezGeneNumber | |
| EntrezGeneSummary | ITAGVencodesintegrinalphachainV.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.TheI-domaincontainingintegrinalphaVundergoespost-translationalcleavagetoyielddisulfide-linkedheavyandlightchains,thatcombinewithmultipleintegrinbetachainstoformdifferentintegrins.Amongtheknownassociatingbetachains(betachains1,3,5,6,and8;"ITGB1","ITGB3","ITGB5","ITGB6",and"ITGB8"),eachcaninteractwithextracellularmatrixligands;thealphaVbeta3integrin,perhapsthemoststudiedofthese,isreferredtoastheVitronectinreceptor(VNR).Inadditiontoadhesion,manyintegrinsareknowntofacilitatesignaltransduction. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P06756#Thealpha-Vintegrinsarereceptorsforvitronectin,cytotactin,fibronectin,fibrinogen,laminin,matrixmetalloproteinase-2,osteopontin,osteomodulin,prothrombin,thrombospondinandvonWillebrandfactor.TheyrecognizethesequenceR-G-Dinawidearrayofligands.IncaseofHIV-1infection,theinteractionwithextracellularviralTatproteinseemstoenhanceangiogenesisinKaposi"ssarcomalesions. SIZE:1048aminoacids;116038Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Thealphasubunitiscomposedofanheavyandalightchainlinkedbyadisulfidebond.Alpha-Vassociateswitheitherbeta-1,beta-3,beta-5,beta-6orbeta-8subunit.InteractswithHIV-1Tat. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P06756##Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats. |
| PhysicochemicalInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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