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Millipore/MAB1398Z | Anti-PECAM-1 Antibody, clone 2H8, Azide Free/MAB1398Z/100 µg
Millipore/MAB1398Z | Anti-PECAM-1 Antibody, clone 2H8, Azide Free/MAB1398Z/100 µg
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1398Z |
| Replaces | 04-1074 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-PECAM-1Antibody,clone2H8,AzideFree |
| AlternateNames |
|
| BackgroundInformation | CD31,alsoknownasplateletendothelialcelladhesionmolecule1(PECAM1),isatypeIintegralmembraneglycoproteinandamemberoftheimmunoglobulinsuperfamilyofcellsurfacereceptors.Itisconstitutivelyexpressedonthesurfaceofendothelialcells,andconcentratedatthejunctionbetweenthem.Itisalsoweaklyexpressedonmanyperipherallymphoidcellsandplatelets. CD31hasbeenusedtomeasureangiogenesisinassociationwithtumorrecurrence.OtherstudieshavealsoindicatedthatCD31andCD34canbeusedasMarkersformyeloidProgenitorcellsandrecognizedifferentsubsetsofmyeloidleukemiainfiltrates(granularsarcomas). |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ProteinAPurifiedmouseimmunoglobulinin20mMsodiumphosphate,250mMNaCl,pH.7.6,containingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor2yearsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | Anti-PECAM-1Antibody,clone2H8,AzideFreedetectslevelofPECAM-1&hasbeenpublished&validatedforuseinElecronMicroscopy,FlowCytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,andNeutralizationAssay. |
| KeyApplications |
|
| ApplicationNotes | ImmunofluorescenceAnalysis:Representativelotsimmunostainedendothelialbloodvesselcellsin4%paraformaldehyde-fixedfrozentumorsectionsfrommiceanddogsasameansforassessinglymphvesseldensityintumorxenograftsbyfluorescentimmunohistochemistry(Donat,U.,etal.(2012).PLoSOne.7(9):e45942;Gentschev,I.,etal.(2012).PLoSOne.7(5):e37239). ImmunofluorescenceAnalysis:Arepresentativelotimmunostainedendothelialcellsinformalin-fixed,paraffin-embeddedmurineperitoneumsectionsbyfluorescentimmunohistochemistry(Tanabe,K.,etal.(2007).KidneyInt.71(3):227-238). ImmunocytochemistryAnalysis:Arepresentativelotimmunostained4%paraformaldehyde-fixedendothelialcellsdifferentiatedfrommurineESCsincultures(Purpura,K.A.,etal.(2008).StemCells.26(11):2832-2842). ImmunocytochemistryAnalysis:Clone2H8immunostained3%paraformaldehyde-fixed,0.5%NP-40-permeABIlizedCOS-7transfectantsexpressingmurine,butnothuman,CD31byfluorescentimmunocytochemistry(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). NeutralizationAnalysis:Arepresentativelot,wheninjectedintravenouslyinmice,blockedleukocyteemigrationinresponsetothioglycollateinjection(Bogen,S.,etal.(1994).J.Exp.Med.179(3):1059-1064). NeutralizationAnalysis:ArepresentativelotblockedmurinePECAM-mediatedaggregationofmouseLcells(Xie,Y.,andMuller,W.A.(1993).Proc.Natl.Acad.Sci.U.S.A.190(12):5569-5573). FlowCytometryAnalysis:ArepresentativelotdetectedtheexpressionofexogenouslytransfectedmurineCD31onthesurfaceofmouseLcells(Xie,Y.,andMuller,W.A.(1993).Proc.Natl.Acad.Sci.U.S.A.190(12):5569-5573). FlowCytometryAnalysis:Clone2H8detectedCD31immunoreactivityonthesurfaceofvariousmurineB-andT-celllines(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). ImmunoprecipitationAnalysis:Arepresentativelotimmunoprecipitatedexogenouslyexpressedmurine,butnothuman,CD31fromCOS-7transfectants(Xie,Y.,andMuller,W.A.(1993).Proc.Natl.Acad.Sci.U.S.A.190(12):5569-5573). ImmunoprecipitationAnalysis:Clone2H8immunoprecipitatedCD31frommurineCTLLTlymphocytesandSp2/0Blymphocytes(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). ElectronMicroscopyAnalysis:Clone2H8wasbiotinylatedandimmunostainedlymphocytesin0.01%glutaraldehyde-/2%formaldehyde-fxedfrozenreactivelymphnodetissuesfromKLH-immunizedmice(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). ImmunohistochemistryAnalysis:Clone2H8immunostainedlymphocytesadherenttothesinusoidalandpostcapillaryvenularendotheliumoffrozenreactivelymphnodetissuesfromKLH-immunizedmice(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | D10.G4.1murineTcells(Bogen,S.A.,etal.(1992).Am.J.Pathol.141(4):843-854). |
| Epitope | Extracellulardomain. |
| Clone | 2H8 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | ArmenianHamster |
| Specificity | Reactswiththe130-140kDaprotein,PECAM-1foundonmousemonocytes,platelets,granulocytesandendothelialcells.2H8effectivelyinhibitstransmigrationofactivatedpolymophonuclearcellsandmonocytesacrosstheendothelium.Inamousemodelforacuteperitonis-2H8blocksacuteinflammation. |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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