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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MAB2130 | Anti-ICAM-1 Antibody, clone W-CAM-1/MAB2130/100 µL
商品详细Millipore/MAB2130 | Anti-ICAM-1 Antibody, clone W-CAM-1/MAB2130/100 µL
Millipore/MAB2130 | Anti-ICAM-1 Antibody, clone W-CAM-1/MAB2130/100 µL
Millipore/MAB2130 | Anti-ICAM-1 Antibody, clone W-CAM-1/MAB2130/100 µL
商品编号: MAB2130
品牌: 密理博
市场价: ¥6580.00
美元价: 3948.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMAB2130
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-ICAM-1Antibody,cloneW-CAM-1
AlternateNames
  • CD54
ProductInformation
FormatAscites
Control
  • POSITIVECONTROL:MOLT-4,Raji,andJurkatcells.
PresentationLiquidcontainingsodiumazide.
StorageandShippingInformation
StorageConditionsMaintainat-20°Cinundilutedaliquotsforuptooneyear.Avoidrepeatedfreeze/thawcycles.
Applications
ApplicationDetectICAM-1usingthisAnti-ICAM-1Antibody,cloneW-CAM-1validatedforuseinFC,IH(P).
KeyApplications
  • FlowCytometry
  • Immunohistochemistry(Paraffin)
ApplicationNotesImmunohistochemistry(formalinfixed,paraffinembeddedtissues):1:20

Flowcytometryonactivatedlymphocytes.

Functionalassaysinadhesionresearch.

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenRAJIcells
CloneW-CAM-1
HostMouse
SpecificityICAM-1belongstotheimmunoglobulinsuperfamily,C2subset.Itisatransmembranemoleculeof90kDwith7potentialN-glycosylationsites.Itisexpressedonrestingmonocytesandendothelialcellsandcanbeupregulatedonmanyothercells,e.g.withlymphokines,onBandTlymphocytes,thymocytes,dendriticcells,keratinocytes,chondrocytes,andepithelialcells.CD54mediatescelladhesionbindingtointegrinsCD11a/CD18(LFA-1)andtoCD11b/CD18(Mac-1).TheinteractionofCD54withLFA-1enhancesantigen-specificTcellactivation.CD54alsobindstoCD43andtoPlasmodiumfalciparum-infectederythrocytes.
IsotypeIgG
SpeciesReactivity
  • Human
  • Rat
SpeciesReactivityNoteDemonstratedtoreactwithratmesenchymalstemcells.
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryICAM1(CD54)istypicallyexpressedonendothelialcellsandcellsoftheimmunesystem.ICAM1bindstointegrinsoftypeCD11a/CD18,orCD11b/CD18.ICAM1isalsoexploitedbyRhinovirusasareceptor.
GeneSymbol
  • ICAM1
  • P3.58
  • BB2
  • CD54
  • ICAM-1
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P05362#ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).Incaseofrhinovirusinfectionactsasacellularreceptorforthevirus.Alsoactsasreceptorforsomecoxsackieviruses.
SIZE:532aminoacids;57825Da
SUBUNIT:Interactswithhumanherpesvirus8MIR2protein(Probable).
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
PTM:Monoubiquitinated,whichispromotedbyMARCH9andleadstoendocytosis.
SIMILARITY:SwissProt:P05362##Belongstotheimmunoglobulinsuperfamily.ICAMfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。