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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MAB336 | Anti-Syntaxin Antibody, clone SP8/MAB336/100 µL
商品详细Millipore/MAB336 | Anti-Syntaxin Antibody, clone SP8/MAB336/100 µL
Millipore/MAB336 | Anti-Syntaxin Antibody, clone SP8/MAB336/100 µL
Millipore/MAB336 | Anti-Syntaxin Antibody, clone SP8/MAB336/100 µL
商品编号: MAB336
品牌: 密理博
市场价: ¥5960.00
美元价: 3576.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMAB336
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-SyntaxinAntibody,cloneSP8
AlternateNames
  • Syntaxin1A
  • Neuron-specificAntigenHPC-1
  • STX1A
ProductInformation
FormatAscites
PresentationLiquidwith0.1%SodiumAzide.
StorageandShippingInformation
StorageConditionsMaintainfrozenat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles.
Applications
ApplicationThisAnti-SyntaxinAntibody,cloneSP8isvalidatedforuseinELISA,WB,IHforthedetectionofSyntaxin.
KeyApplications
  • ELISA
  • WesternBlotting
  • Immunohistochemistry
ApplicationNotesImmunohistochemistryat>1:100-1:200.

Formalinfixed(fixed<4 weeks)="">

Westernblottingat1:100-1:10,000.

ELISAat1:500

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenCrudesynapticimmunoprecipitate(Human).
CloneSP8
HostMouse
SpecificitySyntaxin(34-36kDa).Reactswithsyntaxinexpressedinbacterialsystems.
IsotypeIgG1
SpeciesReactivity
  • Human
  • Hamster
  • Pig
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummarySynapticvesiclesstoreneurotransmittersthatarereleasedduringcalcium-regulatedexocytosis.Thespecificityofneurotransmitterreleaserequiresthelocalizationofbothsynapticvesiclesandcalciumchannelstothepresynapticactivezone.Syntaxinsfunctioninthisvesiclefusionprocess.SyntaxinsalsoserveasasubstrateforbotulinumneurotoxintypeC,ametalloproteasethatblocksexocytosisandhashighaffinityforamolecularcomplexthatincludesthealpha-latrotoxinreceptor(MIM600565)whichproducesexplosiveexocytosis(Zhangetal.,1995[PubMed7622072]).[suppliedbyOMIM]
GeneSymbol
  • STX1A
  • HPC-1
  • STX1
  • Syntaxin-1A
  • p35-1
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:Q16623#Potentiallyinvolvedindockingofsynapticvesiclesatpresynapticactivezones.Mayplayacriticalroleinneurotransmitterexocytosis.
SIZE:288aminoacids;33023Da
SUBUNIT:PartoftheSNAREcorecomplexcontainingSNAP25,VAMP2andSTX1A.ThiscomplexbindstoCPLX1.BindsSYTL4andSTXBP6.FoundinaternarycomplexwithSTX1AandSNAP25(Bysimilarity).FoundinacomplexwithVAMP8andSNAP23.InteractswithVAPAandSYBU.
SUBCELLULARLOCATION:Cellmembrane;Single-passtypeIVmembraneprotein.&Isoform2:Secreted(Probable).
TISSUESPECIFICITY:Isoform1ishighlyexpressedinembryonicspinalchordandgangliaandinadultcerebellumandcerebralcortex.Isoform2isexpressedinheart,liver,fat,skeletalmuscle,kidneyandbrain.
DISEASE:SwissProt:Q16623#HaploinsufficiencyofSTX1Amaybethecauseofcertaincardiovascularandmusculo-skeletalabnormalitiesobservedinWilliams-Beurensyndrome(WBS),araredevelopmentaldisorder.Itisacontiguousgenedeletionsyndromeinvolvinggenesfromchromosomeband7q11.23.
SIMILARITY:SwissProt:Q16623##Belongstothesyntaxinfamily.&Contains1t-SNAREcoiled-coilhomologydomain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。