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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MABN681 | Anti-TrkA Antibody, clone 6B2/MABN681/100 µL
商品详细Millipore/MABN681 | Anti-TrkA Antibody, clone 6B2/MABN681/100 µL
Millipore/MABN681 | Anti-TrkA Antibody, clone 6B2/MABN681/100 µL
Millipore/MABN681 | Anti-TrkA Antibody, clone 6B2/MABN681/100 µL
商品编号: MABN681
品牌: 密理博
市场价: ¥6580.00
美元价: 3948.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMABN681
DescriptionAnti-TrkAAntibody,clone6B2
AlternateNames
  • Highaffinitynervegrowthfactorreceptor
  • Neurotrophictyrosinekinasereceptortype1
  • TRK1-transformingtyrosinekinaseprotein
  • Tropomyosin-relatedkinaseA
  • Tyrosinekinasereceptor
  • TyrosinekinasereceptorA
  • Trk-A
  • gp140trk
  • p140-TrkA
BackgroundInformationTrkA,apparentmolecularweight140kDa,isahighaffinitynervegrowthfactor(NGF).TheTrkproto-oncogenefamilycontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkAbindstonervegrowthfactor(NGF)andautophosphorylatesontyrosineresidues(Tyr490,Tyr674,Tyr675,Tyr751andTyr785)toactivatemultipledownstreameffectorproteins.PhosphorylationatTyr490isrequiredforShcassociationandsubsequentactivationoftheRas-MAPkinase-signalingcascade,whichleadstoactivationofElk-1-dependentgenetranscriptionandneuritegrowth.PhosphorylationsatTyr674andTyr675liewithinthecatalyticdomainofTrkAtyrosinekinaseandreflectTrkkinaseactivity.Additionally,phosphorylationatTyr751isrequiredforPI3-kinaseassociationandactivationoftheAktsignalingcascade.
ProductInformation
FormatAscites
Control
  • Humanbraintissuelysate
PresentationMousemonoclonalIgG2basciticfluidcontainingupto0.1%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
Applications
ApplicationAnti-TrkAAntibody,clone6B2isahighlyspecificmousemonoclonalantibody,thattargetsTrkA&hasbeentestedinwesternblotting,IHC&ICC.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry
  • Immunocytochemistry
ApplicationNotesImmunohistochemistryAnalysis:A1:100dilutionfromarepresentativelotdetectedTrkAinhumanbrainandratcerebellumtissues.

ImmunocytochemistryAnalysis:A1:200-1,000dilutionfromarepresentativelotdetectedTrkAinPC-12cells.

Optimalworkingdilutionsmustbedeterminedbyenduser.
BIOLOGicalInformation
ImmunogenPurifiedrecombinantextracellularfragmentofTrkAexpressedinHEK293cells.
Clone6B2
HostMouse
IsotypeIgG1
SpeciesReactivity
  • Human
  • Rat
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • NTRK1
  • MTC
  • TRK
  • TRKA
PurificationMethodUnpurified
UniProtNumber
MolecularWeight~87kDaobserved.Uncharacterizedbandsmayappearinsomelysate(s).Uniprotdescribes4isoformsrangingbetween~77kDaand~87kDa.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。