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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > Millipore/14-828 | HDAC4, active recombinant protein/14-828/1 each
商品详细Millipore/14-828 | HDAC4, active recombinant protein/14-828/1 each
Millipore/14-828 | HDAC4, active recombinant protein/14-828/1 each
Millipore/14-828 | HDAC4, active recombinant protein/14-828/1 each
商品编号: 14-828
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber14-828
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionHDAC4,activerecombinantprotein
OverviewRecominanthumanHDAC4(a.a.627-end)withN-terminalGST-tag
BackgroundInformationHistonedeacetylationactsatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.HDAC4isahistonedeacetylasewhichdeacetylateslysinesonthecorehistones.HDAC4accumulatesinthenucleiofmyotubes,suggestinginvolvementinmuscledifferentiation.HDAC4doesnotbindDNAdirectlybutinteractswiththemyocyteenhancerfactorsMef2a,Mef2c,andMef2d.HDAC4alsointeractswiththebreastcancer-associatedtranscriptionalrepressorPLU-1/JARID1B,theNr2c1/TR2nuclearreceptor,aswellasthe14-3-3chaperoneprotein,inaphosphorylationdependentmanner.ItalsoformspartofamultiproteincomplexwithRbAp48andHDAC3.
ProductInformation
FormatPurified
Presentation50μgofrecombinantprotienin50mMTris-HCl,pH7.0,150mMNaCl,0.1mMEDTA,1mMdithiothreitol,20%glycerol.Frozensolution.
StorageandShippingInformation
StorageConditionsStoreinaliquotsat-70°C.Avoidfreeze/thawcycles.Formaximumrecoveryofproduct,centrifugeoriginalvialpriortoremovingcap.
Applications
ApplicationRecominanthumanHDAC4(a.a.627-end)withN-terminalGST-tag.
KeyApplications
  • WesternBlotting
  • EnzymeAssays
ApplicationNotesHDACdeacetylaseassays
BIOLOGicalInformation
Concentration0.2mg/ml
PurityPurity>90%bySDS-PAGEandCoomassiebluestaining.
SourceExpressedbybaculovirusinSf9insectcells.
SpecificActivity[Varieswithlot.ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.]LotR0801D0003:2.7U/mg,whereoneunitofHDAC4activityisdefinedas1nmolofassaysubstrate(HDACassaykit,catalog#17-356)deacetylatedperminuteat37°C.
EntrezGeneNumber
GeneSymbol
  • HD4
  • HDAC4
PurificationMethodPurifiedusingglutathione-agarose.GSTportionwascleavedbyPreScission™protease.
UniProtNumber
MolecularWeight49kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。